{"id":"W4389259058","doi":"10.1182/blood-2023-188472","title":"LSD1 Inhibition Enhances Antigen Presentation and Co-Stimulation in AML to Promote T Cell-Mediated Anti-Leukemia Immune Responses","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Juravinski Cancer Centre; Population Health Research Institute; McMaster University","funders":"","keywords":"CIITA; Myeloid leukemia; Leukemia; Cancer research; Antigen; Immune system; Stem cell; Biology; Immunology; Myeloid; Flow cytometry; Downregulation and upregulation; T cell; Transplantation; Medicine; Cell biology; Internal medicine; MHC class II","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406753,0.0002482296,0.0004338959,0.0002470743,0.0001322578,0.0002710998,0.000143182,0.0002101069,0.002187572],"category_scores_gemma":[0.00009563207,0.00009777907,0.0003072008,0.0001563266,0.0001835937,0.0001566423,0.0002206575,0.0007108028,0.0005456296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002545658,"about_ca_system_score_gemma":0.0001833601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003694165,"about_ca_topic_score_gemma":0.0007689224,"domain_scores_codex":[0.9998654,0.00001649426,0.00001337737,0.00002351645,0.00003612049,0.00004505117],"domain_scores_gemma":[0.9999479,0.000008923688,0.000009866561,0.000004881773,0.000006277365,0.00002202595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000298058,0.00008944453,0.0001983897,0.00008596842,0.000007171093,0.00004139458,0.00002130568,0.00009454264,0.9963416,0.00007889282,0.0001773297,0.002565922],"study_design_scores_gemma":[0.00005740488,0.0007486761,0.003297986,0.000006587772,0.00001915218,0.0001541904,0.00003009673,0.0008175212,0.9911687,0.00004806926,0.003645902,0.000005664518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926984,0.002588435,0.001616391,0.0001788979,0.0000730313,0.00004656758,0.0004595091,0.0001766785,0.002162163],"genre_scores_gemma":[0.9949421,0.0008258949,0.001070147,0.00009292726,0.00001391439,0.00004003497,0.000616723,0.00001489615,0.002383386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002187572,"threshold_uncertainty_score":0.007318199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269100053148129,"score_gpt":0.2660407128686262,"score_spread":0.2533497123371449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}