{"id":"W4389259463","doi":"10.1182/blood-2023-190062","title":"The KIR-HLA-CD16a Immunogenetic Profile Influences NK Cell-Mediated ADCC and Response to Rituximab Therapy in B-Cell Lymphomas","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Antibody-dependent cell-mediated cytotoxicity; Immunology; Rituximab; B cell; CD20; Biology; Human leukocyte antigen; Cancer research; Lymphoma; Antibody; Antigen; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003702224,0.0001883887,0.0002801298,0.0003640394,0.00009639363,0.0003532217,0.0001341585,0.0002297204,0.001298696],"category_scores_gemma":[0.000954703,0.0001145443,0.0001743033,0.0002278242,0.00017066,0.0001575764,0.0001533113,0.0002509053,0.0003524111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001323944,"about_ca_system_score_gemma":0.0001043495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003879749,"about_ca_topic_score_gemma":0.0003305319,"domain_scores_codex":[0.9997459,0.0001022213,0.00002907689,0.00004813214,0.00004157009,0.00003306831],"domain_scores_gemma":[0.9993992,0.0002155778,0.0002085862,0.00003562529,0.00004339008,0.00009767406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002931988,0.0004113372,0.4269048,0.0000648009,0.0001533003,0.0005150802,0.0001983179,0.0003773514,0.5530993,0.00006363796,0.00009281627,0.01518717],"study_design_scores_gemma":[0.00004890838,0.001516292,0.960829,0.00001179281,0.0001335118,0.002610242,0.000118526,0.001279132,0.03276797,0.0001291493,0.0005437557,0.00001179328],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995479,0.000184448,0.0001057287,0.000005756242,0.000001476364,0.000003070762,0.00002269536,0.000003237775,0.0001256667],"genre_scores_gemma":[0.9996758,0.00005526622,0.0001092911,0.000008168779,0.000001904112,0.000003120087,0.00003424705,0.00000342031,0.0001088648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298696,"threshold_uncertainty_score":0.004344583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008601615872810036,"score_gpt":0.2244463639005053,"score_spread":0.2158447480276953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}