{"id":"W4389259512","doi":"10.1182/blood-2023-188135","title":"Asciminib Enhances Its Treatment Efficacy Synergistically in the Treatment of Chronic Myeloid Leukemia Harboring ABL1 Kinase Domain Mutation When Combined with a Reduced Dose of Ponatinib, Dasatinib, or Bosutinib, but Not with Nilotinib or Imatinib","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Bosutinib; Dasatinib; Ponatinib; Nilotinib; Imatinib; Medicine; Myeloid leukemia; Pharmacology; Tyrosine-kinase inhibitor; Tyrosine kinase; Imatinib mesylate; Cancer research; Internal medicine; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003365358,0.00042787,0.0005662053,0.0003347905,0.0001644181,0.0004401651,0.0002589313,0.0002270111,0.003139388],"category_scores_gemma":[0.0001527828,0.0001313652,0.0004238005,0.0003063704,0.0003098885,0.0003522067,0.0002310463,0.000824982,0.0004650357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002892085,"about_ca_system_score_gemma":0.0004052072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002505353,"about_ca_topic_score_gemma":0.0006912668,"domain_scores_codex":[0.9998387,0.00004880833,0.00001053609,0.00002543457,0.00003180413,0.00004467377],"domain_scores_gemma":[0.9999105,0.00001723637,0.00001749826,0.000009919336,0.000009537276,0.00003528209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02472346,0.006949905,0.002783729,0.00111889,0.00030146,0.0003496157,0.0002125975,0.002071783,0.797482,0.000708377,0.004059162,0.1592391],"study_design_scores_gemma":[0.008544317,0.1540494,0.03533081,0.0001168995,0.0009493682,0.003236711,0.0001928814,0.0050361,0.7579647,0.000458169,0.03403234,0.0000884175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889705,0.004452136,0.0005806969,0.0003105584,0.0001247981,0.0001433049,0.0003232581,0.000124332,0.004970451],"genre_scores_gemma":[0.9959697,0.001281406,0.0009272608,0.00009977206,0.00004787956,0.0000529022,0.0003207376,0.00001140561,0.001289051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003139388,"threshold_uncertainty_score":0.01050228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03312461366678398,"score_gpt":0.2947581460343663,"score_spread":0.2616335323675823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}