{"id":"W4389259576","doi":"10.1182/blood-2023-190255","title":"Skp2 Inhibition Diminishes Essential Cell Survival Markers c-Maf and c-Myc, Enhancing Therapeutic Efficacy Against Drug Resistant Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Gene knockdown; Multiple myeloma; Cancer research; Malignancy; Medicine; Cell culture; Biology; Internal medicine; Oncology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145718,0.0003287795,0.0004148506,0.0002681557,0.0001296044,0.0003132644,0.000173274,0.0001898144,0.001369537],"category_scores_gemma":[0.0001260624,0.0001303484,0.0002692041,0.0003456822,0.0001458193,0.000167716,0.0001330622,0.0006248635,0.0003187827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244856,"about_ca_system_score_gemma":0.0002617947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006900379,"about_ca_topic_score_gemma":0.002035899,"domain_scores_codex":[0.9998678,0.00001189552,0.00001386805,0.00002882869,0.00004666279,0.0000309926],"domain_scores_gemma":[0.999946,0.000009934409,0.00001582624,0.000006753655,0.000006769905,0.00001465543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005195804,0.0001109813,0.0008055451,0.0001611275,0.00004540264,0.00004571734,0.00002113796,0.0003601173,0.991687,0.0000813467,0.0007020798,0.005459979],"study_design_scores_gemma":[0.0001034737,0.001132461,0.0235934,0.0000154765,0.000104843,0.0003210596,0.00004645367,0.002363153,0.963745,0.00009110283,0.008470196,0.00001320218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899023,0.003514946,0.001107594,0.0001957087,0.00005017579,0.00003463892,0.003501459,0.0002345294,0.001458632],"genre_scores_gemma":[0.9901659,0.002008507,0.001247961,0.0001134164,0.00001561357,0.0000583312,0.004480159,0.00002918181,0.001881055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369537,"threshold_uncertainty_score":0.004581571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713314300439548,"score_gpt":0.2693065449417396,"score_spread":0.2521734019373441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}