{"id":"W4389259609","doi":"10.1182/blood-2023-186142","title":"mRNA Translation Inhibition Targets Bioenergetic Homeostasis in AML Cells <i>in Vitro</i> and <i>In Vivo</i> and Synergizes with Cytarabine and Venetoclax","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Concordia University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"mTORC1; Biology; Cancer research; Myeloid leukemia; Venetoclax; Cytarabine; Myeloid; Leukemia; Cancer cell; Cancer; PI3K/AKT/mTOR pathway; Cell biology; Chronic lymphocytic leukemia; Immunology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555011,0.000423028,0.0003659097,0.0002398021,0.0001585006,0.0004100667,0.0002288156,0.0002557144,0.001846689],"category_scores_gemma":[0.0001327111,0.0001228202,0.0003478729,0.000159306,0.0002442007,0.0001921982,0.0001659111,0.001141407,0.0005231864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372993,"about_ca_system_score_gemma":0.0003477262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007487979,"about_ca_topic_score_gemma":0.001436981,"domain_scores_codex":[0.9998702,0.00002350185,0.00001364893,0.00002264032,0.00003792733,0.00003200064],"domain_scores_gemma":[0.9999399,0.00001096354,0.0000149332,0.00001040148,0.000007077902,0.0000168199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008960307,0.0003336058,0.0002785887,0.0001196668,0.00002313504,0.00004701925,0.00002224911,0.0003201748,0.9850251,0.0003187867,0.001143515,0.01147215],"study_design_scores_gemma":[0.0001646873,0.003932274,0.003469059,0.00001449446,0.00006549492,0.0002259832,0.00003433998,0.001178398,0.979408,0.0001233151,0.011375,0.000008963092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734033,0.007781572,0.003707611,0.0009077962,0.0005683762,0.0001378541,0.001012244,0.0006825941,0.01179859],"genre_scores_gemma":[0.9904986,0.002811077,0.001444598,0.0002484346,0.00005783838,0.00009920355,0.001124947,0.00004303475,0.003672237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846689,"threshold_uncertainty_score":0.006177843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114590323882107,"score_gpt":0.2371572518239038,"score_spread":0.2260113485850827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}