{"id":"W4389261506","doi":"10.1158/2326-6074.tumimm23-a042","title":"Abstract A042: Quantitative multiplex immunoprecipitation reveals distinct protein interaction networks responsible for discrepant <i>in vivo</i> activity exhibited by two second generation CD22-targeted chimeric antigen receptors","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chimeric antigen receptor; Multiplex; CD19; Antigen; CD22; Immunoprecipitation; In vivo; Cancer research; MUC1; CD28; Immunotherapy; Biology; Computational biology; Immunology; Antibody; CD8; Immune system; Bioinformatics; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003159682,0.0003818872,0.0002781455,0.0003841452,0.0002238782,0.0007835388,0.0002800115,0.0003556863,0.003331956],"category_scores_gemma":[0.0002722924,0.0001705694,0.000324225,0.0002696239,0.0001874863,0.0001906237,0.0001256701,0.0006451067,0.0008634166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003937505,"about_ca_system_score_gemma":0.0001883075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000461754,"about_ca_topic_score_gemma":0.0005751158,"domain_scores_codex":[0.9997379,0.00003562513,0.0000144368,0.00009670146,0.00006040801,0.00005488245],"domain_scores_gemma":[0.9998772,0.00003561501,0.00002644795,0.00001412608,0.00001870257,0.00002788483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005943182,0.00009025708,0.0009839479,0.00002682608,0.00002122577,0.00004139003,0.00001204381,0.00015502,0.9957839,0.0001355073,0.0004192961,0.001736178],"study_design_scores_gemma":[0.0001237932,0.0005298834,0.02722113,0.000006938495,0.00006060622,0.0006393148,0.00004868927,0.01516724,0.952601,0.000230047,0.003353086,0.00001836071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902729,0.0006095796,0.00554398,0.0002309466,0.00004448864,0.00003650083,0.001154774,0.000225905,0.001880859],"genre_scores_gemma":[0.991483,0.0002696191,0.003504067,0.0001595076,0.00002734992,0.00005968972,0.001937732,0.00004945031,0.002509576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003331956,"threshold_uncertainty_score":0.01114649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110642313262344,"score_gpt":0.4368358340781467,"score_spread":0.3257716027519124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}