{"id":"W4389263633","doi":"10.1002/alz.13550","title":"Association of <i>MGMT</i> and <i>BIN1</i> genes with Alzheimer's disease risk across sex and <i>APOE</i> ε4 status","year":2023,"lang":"en","type":"letter","venue":"Alzheimer s & Dementia","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"Instituto de Salud Carlos III; Medical Research Council; Grifols; Agence Nationale de la Recherche; Norges Forskningsråd; Fondation pour la Recherche sur Alzheimer; Bundesministerium für Bildung und Forschung","keywords":"Apolipoprotein E; Disease; Gene; Gerontology; Biology; Medicine; Genetics; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008334182,0.001703934,0.003296973,0.001638639,0.0006181151,0.002246944,0.001168479,0.00158114,0.001739768],"category_scores_gemma":[0.01501645,0.0007740529,0.01578766,0.00285502,0.0005819887,0.0006912282,0.0009403626,0.001546056,0.0002033924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000811403,"about_ca_system_score_gemma":0.0007692358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01038216,"about_ca_topic_score_gemma":0.0121846,"domain_scores_codex":[0.996372,0.001638056,0.0005373098,0.0009809142,0.0002722954,0.0001995281],"domain_scores_gemma":[0.9908785,0.006347533,0.001164456,0.0008401551,0.0005511438,0.0002181903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.01435777,0.00007403047,0.2086665,0.01312128,0.7365261,0.0003145244,0.0001600996,0.001055285,0.003422891,0.0003817035,0.001195627,0.0207241],"study_design_scores_gemma":[0.001749055,0.0007570609,0.1208458,0.001477836,0.8684413,0.0004227275,0.00006323445,0.001058576,0.001458166,0.0009838184,0.002695007,0.00004743165],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.4031776,0.5796762,0.005787495,0.003001721,0.001114321,0.0004266446,0.003826335,0.0002067953,0.002782879],"genre_scores_gemma":[0.9506726,0.04185241,0.002708375,0.001871994,0.0005600755,0.0002441017,0.001467739,0.00005910385,0.0005636159],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01038216,"threshold_uncertainty_score":0.04407585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249648870091732,"score_gpt":0.2530902415876092,"score_spread":0.2405937528866919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}