{"id":"W4389264009","doi":"10.3390/vaccines11121805","title":"Prophylactic Vaccination and Intratumoral Boost with HER2-Expressing Oncolytic Herpes Simplex Virus Induces Robust and Persistent Immune Response against HER2-Positive Tumor Cells","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Herpes simplex virus; Immune system; Antibody-dependent cell-mediated cytotoxicity; Cancer research; Immunology; Antibody; Immunotherapy; Medicine; NKG2D; Virus; Virology; Cytotoxicity; Biology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004773363,0.0002762997,0.0002441505,0.0001690019,0.0002784298,0.0001689588,0.0001555616,0.0001048886,0.00001410765],"category_scores_gemma":[0.00008717931,0.0002302023,0.00005607088,0.000322141,0.00006852933,0.00002584696,0.0001678392,0.0001463059,0.000007916911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004398547,"about_ca_system_score_gemma":0.0001616005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005684897,"about_ca_topic_score_gemma":0.0001183231,"domain_scores_codex":[0.9983005,0.0003060767,0.0002328491,0.00054309,0.0002116219,0.0004058593],"domain_scores_gemma":[0.9992027,0.00007877737,0.0001209269,0.0002982774,0.0001641694,0.0001351533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01095868,0.00009076557,0.0002161983,0.00008446302,0.00008403379,0.0000572851,0.0003128847,0.0004528872,0.9743223,6.802577e-7,0.0001442335,0.01327558],"study_design_scores_gemma":[0.001702569,0.004652883,0.02683266,0.00006572637,0.00004133651,0.00004063462,0.001044155,0.0008279376,0.9638011,0.000008122143,0.0006125622,0.0003703375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972075,0.001475139,0.000009130557,0.0006001928,0.00005367056,0.0005255545,0.00003418367,0.00004319159,0.00005145677],"genre_scores_gemma":[0.9986785,0.0003262077,0.0001329609,0.0001512597,0.0001329358,0.00005995819,0.00007423522,0.00005770818,0.0003861999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02661646,"threshold_uncertainty_score":0.9387377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782311759592673,"score_gpt":0.2724897284151188,"score_spread":0.2546666108191921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}