{"id":"W4389264009","doi":"10.3390/vaccines11121805","title":"Prophylactic Vaccination and Intratumoral Boost with HER2-Expressing Oncolytic Herpes Simplex Virus Induces Robust and Persistent Immune Response against HER2-Positive Tumor Cells","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Herpes simplex virus; Immune system; Antibody-dependent cell-mediated cytotoxicity; Cancer research; Immunology; Antibody; Immunotherapy; Medicine; NKG2D; Virus; Virology; Cytotoxicity; Biology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077461,0.0003771646,0.0003222426,0.0001520311,0.00007428145,0.0002143242,0.0001567707,0.000238194,0.0005910221],"category_scores_gemma":[0.0000753417,0.00008505597,0.000155214,0.0000950012,0.0002019214,0.0001814375,0.0001398646,0.0006727827,0.0001379649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001798652,"about_ca_system_score_gemma":0.0002414816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002145103,"about_ca_topic_score_gemma":0.0002918986,"domain_scores_codex":[0.9999008,0.00001284458,0.000005976054,0.00002511539,0.00002036336,0.00003482816],"domain_scores_gemma":[0.9999473,0.000007532661,0.00001669843,0.00001056958,0.000003767543,0.00001412652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001362537,0.0001191459,0.0001246946,0.00001727459,0.000003052087,0.00001392563,0.000006224423,0.00006287417,0.9980358,0.00008548978,0.0000199457,0.001375307],"study_design_scores_gemma":[0.00004407062,0.001925009,0.001479816,0.000005077431,0.00001565929,0.0002316154,0.00001041385,0.0007563331,0.9942444,0.0000540916,0.001230412,0.000003013832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956239,0.0007168415,0.002603598,0.0000428464,0.0000299432,0.00005223712,0.00008208167,0.00008182431,0.0007668239],"genre_scores_gemma":[0.9967943,0.0003764359,0.001851207,0.00002514121,0.00001390994,0.00002784704,0.0001478805,0.000009038525,0.0007542571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005910221,"threshold_uncertainty_score":0.001977146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782311759592673,"score_gpt":0.2724897284151188,"score_spread":0.2546666108191921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}