{"id":"W4389269480","doi":"10.1080/15548627.2023.2286414","title":"Basal activity of PINK1 and PRKN in cell models and rodent brain","year":2023,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Aging; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Florida Department of Health; Congressionally Directed Medical Research Programs; Mayo Clinic; American Parkinson Disease Association; U.S. Department of Defense","keywords":"PINK1; Mitophagy; Biology; Autophagy; Ubiquitin ligase; Ubiquitin; Cell biology; Parkin; Mitochondrion; Basal (medicine); Parkinson's disease; Neuroscience; Disease; Internal medicine; Endocrinology; Apoptosis; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000376408,0.0004914409,0.0004447915,0.0009655051,0.000294011,0.0005362043,0.0002983587,0.0003456191,0.001285816],"category_scores_gemma":[0.0002330829,0.0002157942,0.0003195678,0.0005699063,0.0005771118,0.0005534967,0.000319319,0.001035545,0.0005313212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004819868,"about_ca_system_score_gemma":0.000397091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009884476,"about_ca_topic_score_gemma":0.002536555,"domain_scores_codex":[0.9994639,0.00009467416,0.00007018866,0.0001474108,0.0001233455,0.0001006365],"domain_scores_gemma":[0.9997876,0.00003592072,0.00005792874,0.00004022845,0.00002939838,0.00004891916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004713211,0.0001312586,0.0008073738,0.00008274394,0.00001816759,0.0001339677,0.00008275308,0.0001300055,0.9955766,0.0002136445,0.000140381,0.002211836],"study_design_scores_gemma":[0.00001246579,0.0007629958,0.005055577,0.0000107181,0.00004137264,0.0004838061,0.0001221813,0.000335502,0.9911304,0.0001074514,0.001928323,0.000009159678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682966,0.01010001,0.01396728,0.0002308803,0.0001268974,0.0001339276,0.002371936,0.0003790075,0.004393528],"genre_scores_gemma":[0.9774554,0.005749526,0.009026308,0.0001323665,0.00002251775,0.0003028181,0.003120133,0.00008595161,0.004105029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285816,"threshold_uncertainty_score":0.004301488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02310461190578223,"score_gpt":0.2926898597496608,"score_spread":0.2695852478438786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}