{"id":"W4389271466","doi":"10.53063/synsint.2023.34183","title":"Unlocking the potential of aromatase inhibitors: recent advances in drug design, synthesis, docking activity, and in vitro bioactivity evaluations","year":2023,"lang":"en","type":"article","venue":"Synthesis and Sintering","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Aromatase; ADME; Anastrozole; Docking (animal); Drug discovery; Curcumin; Pharmacology; DOCK; Estrogen receptor; Computational biology; Chemistry; Drug; Exemestane; Breast cancer; Biology; Medicine; Cancer; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007478332,0.0001232777,0.0001739224,0.0001201354,0.00008364925,0.00002808382,0.000074683,0.00007562917,0.000001876024],"category_scores_gemma":[0.0003020383,0.00009510131,0.00003867839,0.0001722763,0.00008479939,0.00001874777,0.000146101,0.0001028014,5.714594e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000155453,"about_ca_system_score_gemma":0.00002290028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005269166,"about_ca_topic_score_gemma":0.00004785185,"domain_scores_codex":[0.9990236,0.000265033,0.000175713,0.0002503485,0.00009715506,0.0001881121],"domain_scores_gemma":[0.9994895,0.0002438737,0.00007898616,0.0001410751,0.00001491826,0.00003161433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001731725,0.0000331039,0.000409942,0.00003560922,0.0000196959,0.000007033218,0.00007883884,0.0006974172,0.8843864,0.000001268882,0.000005894404,0.1141516],"study_design_scores_gemma":[0.0001455681,0.00002362422,0.003857099,0.0002101936,0.0000215938,0.00001172153,0.0002724365,0.003337723,0.9918686,0.00003765734,0.0001031641,0.0001106832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955037,0.003760447,0.0002260955,0.0001934258,0.00006770618,0.000186229,0.000009825311,0.000009565787,0.00004296634],"genre_scores_gemma":[0.9929646,0.006841266,0.00009152142,0.000004930326,0.00003281203,0.00004580489,0.000003242798,0.000012933,0.000002894383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.114041,"threshold_uncertainty_score":0.3878119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170369780719535,"score_gpt":0.2715015391937214,"score_spread":0.2597978413865261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}