{"id":"W4389280326","doi":"10.1016/j.celrep.2023.113551","title":"Single-cell RNA sequencing uncovers the cell type-dependent transcriptomic changes in the retrosplenial cortex after peripheral nerve injury","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Fundamental Research Funds for the Central Universities; Wuhan University School of Medicine; National Natural Science Foundation of China; National University's Basic Research Foundation of China; Zhejiang University; Ministry of Education - Singapore","keywords":"Retrosplenial cortex; Chromatin structure remodeling (RSC) complex; Neuropathic pain; Neuroscience; Peripheral nerve injury; Transcriptome; Nerve injury; Excitatory postsynaptic potential; Nucleus; Chemistry; Medicine; Biology; Anesthesia; Cortex (anatomy); Inhibitory postsynaptic potential; Transcription factor; Biochemistry; Gene; Gene expression; Sciatic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308902,0.0002342283,0.0002744824,0.0003814624,0.0001551261,0.0003618673,0.0001648904,0.000212722,0.0006318824],"category_scores_gemma":[0.0002119005,0.0001403162,0.0002847432,0.0002097867,0.0002789831,0.0001664887,0.0001938655,0.0004221854,0.0002779551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001807023,"about_ca_system_score_gemma":0.0001931865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007417201,"about_ca_topic_score_gemma":0.001798455,"domain_scores_codex":[0.9998816,0.000006744261,0.000007753719,0.00004439512,0.00002841753,0.00003105172],"domain_scores_gemma":[0.9998367,0.00002001516,0.00006059135,0.00001818103,0.00003202699,0.0000324311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008205212,0.000005334945,0.001201274,0.00002921359,0.00001305456,0.00003534062,0.00002328546,0.00005256225,0.9972606,0.00003540074,0.0000348236,0.001227175],"study_design_scores_gemma":[0.00002681226,0.0003815762,0.3343517,0.00002975901,0.0001408685,0.0007764517,0.0003674364,0.002949709,0.6568564,0.0004812141,0.003603392,0.00003476826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886947,0.001225672,0.006427472,0.00008924124,0.00002553188,0.00002679735,0.00254265,0.0001049344,0.000862996],"genre_scores_gemma":[0.9871178,0.001148711,0.00603461,0.0001883745,0.00001511072,0.00008768477,0.003129443,0.0000668724,0.002211495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007417201,"threshold_uncertainty_score":0.002113819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03151121545731708,"score_gpt":0.2396549886164679,"score_spread":0.2081437731591509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}