{"id":"W4389291803","doi":"10.1002/jgm.3642","title":"Surface modification of lipid nanoparticles for gene therapy","year":2023,"lang":"en","type":"review","venue":"The Journal of Gene Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research - Antimicrobial Resistance Research Initiative; Stiftung Charité; LEO Fondet; Mitacs","keywords":"Endosome; Gene delivery; Genetic enhancement; Nucleic acid; Systemic administration; Cell; Computational biology; Gene; Nanotechnology; Chemistry; Biology; Cell biology; Biochemistry; Biotechnology; In vivo; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001191813,0.0001829559,0.0007486573,0.00006407101,0.00003840851,0.000003537717,0.0004713382,0.0001334524,0.000008332875],"category_scores_gemma":[0.0001280623,0.00009420975,0.0002695346,0.0001257292,0.0001094641,0.000002284178,0.00002991671,0.0001098934,0.000004186586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001226861,"about_ca_system_score_gemma":0.0001748274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007506788,"about_ca_topic_score_gemma":0.000001699494,"domain_scores_codex":[0.9986186,0.0001526798,0.0007833214,0.0001175264,0.0001871545,0.0001406914],"domain_scores_gemma":[0.9982589,0.0001045051,0.0009360767,0.0003340446,0.0003161889,0.00005021202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002565487,0.00004646766,0.000001855268,0.0009730015,0.0006711445,0.000001517869,0.0001461046,0.0000888477,0.7359056,0.000003977545,0.01137803,0.2505269],"study_design_scores_gemma":[0.000793579,0.002591659,0.000006042027,0.002376119,0.0007590765,0.000148239,0.00012812,0.000009808542,0.2626803,0.00005906569,0.7302789,0.0001690669],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03075083,0.9677565,0.0005610866,0.0001916142,0.0003826277,0.0003115444,0.00003048555,0.000002289759,0.00001309033],"genre_scores_gemma":[0.001599323,0.9964462,0.0001585346,0.00005147134,0.001270867,0.000005994961,0.00006766547,0.00003301578,0.0003669355],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7189009,"threshold_uncertainty_score":0.3841762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1345592046570512,"score_gpt":0.3828724326885729,"score_spread":0.2483132280315217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}