{"id":"W4389291803","doi":"10.1002/jgm.3642","title":"Surface modification of lipid nanoparticles for gene therapy","year":2023,"lang":"en","type":"review","venue":"The Journal of Gene Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research - Antimicrobial Resistance Research Initiative; Stiftung Charité; LEO Fondet; Mitacs","keywords":"Endosome; Gene delivery; Genetic enhancement; Nucleic acid; Systemic administration; Cell; Computational biology; Gene; Nanotechnology; Chemistry; Biology; Cell biology; Biochemistry; Biotechnology; In vivo; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545039,0.0007483737,0.0005888871,0.0009150574,0.0001399633,0.0005093859,0.0004636856,0.0008664618,0.002015518],"category_scores_gemma":[0.0002027034,0.0002443045,0.0004275711,0.0006465375,0.0002825513,0.000627096,0.0004198068,0.001112072,0.001563541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004672002,"about_ca_system_score_gemma":0.0003324673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004188264,"about_ca_topic_score_gemma":0.0005341575,"domain_scores_codex":[0.9998556,0.00002263101,0.00000922064,0.00002577744,0.0000675337,0.00001918004],"domain_scores_gemma":[0.9999588,0.000015081,0.000008166146,0.000002659694,0.00001108712,0.000004174261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007699615,0.0001319827,0.000150356,0.01584993,0.000111995,0.0005694149,0.0001017385,0.001470358,0.1543888,0.01707216,0.02248964,0.7875866],"study_design_scores_gemma":[0.00001642153,0.0001759816,0.0004435847,0.000956381,0.00007512396,0.001516454,0.00002894936,0.0005992827,0.04521611,0.002638482,0.9483084,0.00002491477],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002093259,0.9861816,0.003696595,0.0003014364,0.0005463625,0.00003726119,0.00003981562,0.00005278946,0.007051013],"genre_scores_gemma":[0.01445877,0.9756615,0.002903017,0.0004085781,0.000201145,0.00006154628,0.00007994206,0.00001457382,0.006210896],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002015518,"threshold_uncertainty_score":0.006742597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1345592046570512,"score_gpt":0.3828724326885729,"score_spread":0.2483132280315217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}