{"id":"W4389295985","doi":"10.1139/bcb-2023-0223","title":"Yeast profilin mutants inhibit classical nuclear import and alter the balance between actin and tubulin levels","year":2023,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Universität des Saarlandes","keywords":"Profilin; Yeast; Biology; Saccharomyces cerevisiae; Tubulin; Cell biology; Actin; Fungal protein; MDia1; Actin remodeling; Actin-binding protein; Biochemistry; Microtubule; Cytoskeleton; Actin cytoskeleton; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376368,0.0001545042,0.0001468874,0.00001437712,0.0001339409,0.00002393856,0.00008161999,0.0003098969,0.0000202854],"category_scores_gemma":[0.00003120629,0.0001128367,0.00002948739,0.00006105955,0.0002870054,0.000003218326,0.0001923698,0.0001522152,0.000008904895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003698614,"about_ca_system_score_gemma":0.00002051039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003323456,"about_ca_topic_score_gemma":8.663703e-7,"domain_scores_codex":[0.9991364,0.00003611091,0.0001455284,0.0004155891,0.0000428511,0.0002235136],"domain_scores_gemma":[0.9996279,0.00001821563,0.0000585967,0.0001897287,0.00001812863,0.00008745745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005237505,0.000006494065,0.008525123,0.00003107957,0.00002216826,0.000002537417,0.00002620413,7.028145e-8,0.9843037,0.00001963235,0.001524061,0.005486619],"study_design_scores_gemma":[0.0005384778,0.0002053941,0.02251426,0.000009155871,0.00003050249,0.00005499609,0.0001852042,0.00004989279,0.8932416,0.0001385294,0.08279658,0.0002354161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979182,0.0004457899,0.000006243803,0.0005570291,0.00007193221,0.00009505988,0.00008029089,0.00002125754,0.0008041325],"genre_scores_gemma":[0.997923,0.0002997145,0.00005777546,0.0002439807,0.000414102,0.000005254557,0.0001362749,0.00001621433,0.0009037505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09106205,"threshold_uncertainty_score":0.4601347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079384725126482,"score_gpt":0.2345992273067352,"score_spread":0.2238053800554704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}