{"id":"W4389296199","doi":"10.1182/blood.2023021234","title":"Transcriptional control of leukemogenesis by the chromatin reader SGF29","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Chromatin; Biology; Transcription factor; Myeloid leukemia; CRISPR; Leukemia; Computational biology; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193642,0.0000600276,0.0000635566,0.0000158612,0.00004398029,0.000005975465,0.0001080974,0.00005791572,0.00003768424],"category_scores_gemma":[0.00003498875,0.00004373603,0.00006337023,0.0000840417,0.00005227392,0.000001517962,0.00001212576,0.00002686604,0.00001876912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001805411,"about_ca_system_score_gemma":0.0000312715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009422175,"about_ca_topic_score_gemma":0.000002987603,"domain_scores_codex":[0.999522,0.00003901434,0.0001240678,0.0001133703,0.0001042666,0.00009722303],"domain_scores_gemma":[0.9997407,0.000008982372,0.00003963301,0.0001563263,0.00003127264,0.00002307956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001044802,0.00004545406,0.0004359695,0.000006402879,0.00004457936,2.974103e-7,0.00001629593,0.000004537423,0.9857931,0.0001447492,0.0130301,0.0004681368],"study_design_scores_gemma":[0.001091236,0.00007152768,0.0029756,0.000004359309,0.00002345183,0.00000471282,0.00003869585,0.00003034696,0.9507397,0.00002826159,0.04493098,0.00006111174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996334,0.001110132,0.0007154958,0.0008392738,0.00006486725,0.0001496445,0.00009761112,0.00001805167,0.0006709328],"genre_scores_gemma":[0.9980188,0.00006738312,0.00005251857,0.0002393383,0.0001063567,0.00003032678,0.000147794,0.000008819208,0.001328652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03505332,"threshold_uncertainty_score":0.1783504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008717274433925162,"score_gpt":0.2157868901338971,"score_spread":0.2070696156999719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}