{"id":"W4389297942","doi":"10.1021/acschemneuro.3c00681","title":"Synthesis and Preclinical Evaluation of 22-[<sup>18</sup>F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Aging; Alzheimer's Drug Discovery Foundation","keywords":"Docosahexaenoic acid; Positron emission tomography; In vivo; Polyunsaturated fatty acid; Metabolism; Pharmacology; Biochemistry; Chemistry; Medicine; Biology; Fatty acid; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003444512,0.000726082,0.0003434565,0.0002806355,0.0002112848,0.0002955311,0.000473018,0.0006974888,0.001573087],"category_scores_gemma":[0.0002242363,0.0002709936,0.0002532334,0.0002161377,0.000278594,0.0003654217,0.0001715948,0.0009251283,0.0005988092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345891,"about_ca_system_score_gemma":0.0004563361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086701,"about_ca_topic_score_gemma":0.001261184,"domain_scores_codex":[0.9999132,0.00002094081,0.000005297556,0.00001918806,0.00001955353,0.00002182806],"domain_scores_gemma":[0.9998286,0.00002057664,0.00004286328,0.00002165244,0.00003809745,0.00004815045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006886824,0.0002315278,0.00009987788,0.000176156,0.00002874985,0.0001386029,0.00003534805,0.000558758,0.9904594,0.0002814112,0.0003661342,0.006935372],"study_design_scores_gemma":[0.0001910465,0.005481142,0.0006204187,0.00001728724,0.00008934583,0.0003422266,0.0000306582,0.0008360829,0.9797143,0.00007326867,0.01258654,0.00001765314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9227782,0.0157705,0.04621519,0.0008674603,0.0002517914,0.001474792,0.002943377,0.0004266085,0.009271958],"genre_scores_gemma":[0.9414762,0.01494581,0.03004594,0.0004698719,0.00008158144,0.001023366,0.002673557,0.0001199802,0.009163644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001573087,"threshold_uncertainty_score":0.005262494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05283920513904707,"score_gpt":0.3513292718129812,"score_spread":0.2984900666739342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}