{"id":"W4389303227","doi":"10.1016/j.jacc.2023.10.007","title":"Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials","year":2023,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Discontinuation; Adverse effect; Tolerability; Incidence (geometry); Internal medicine; Placebo; Population; Creatinine; Post-hoc analysis; Hazard ratio; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01169385,0.0006219711,0.001837501,0.0005548024,0.0005041163,0.001145051,0.0006208539,0.00100048,0.006185499],"category_scores_gemma":[0.008860486,0.0003101604,0.002265972,0.000733078,0.0004401806,0.0006114874,0.000415719,0.001508498,0.0007188494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000591334,"about_ca_system_score_gemma":0.001367964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001867783,"about_ca_topic_score_gemma":0.0008235666,"domain_scores_codex":[0.9936755,0.004432349,0.000750891,0.0003619564,0.0005700223,0.0002091923],"domain_scores_gemma":[0.9912984,0.00397454,0.002810884,0.0004428464,0.0009137978,0.0005595074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.637856,0.004589876,0.03171776,0.01622221,0.01505973,0.0005437169,0.0004757681,0.002008481,0.01619721,0.0009020853,0.008571453,0.2658557],"study_design_scores_gemma":[0.6085394,0.2282453,0.08441494,0.00336227,0.01705067,0.001248195,0.0002391946,0.003288564,0.008326393,0.001576103,0.04358456,0.0001242768],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8670427,0.09988254,0.003062695,0.001932302,0.0004334528,0.009944124,0.003214584,0.0001877982,0.01429975],"genre_scores_gemma":[0.9441013,0.0290225,0.006020103,0.002278863,0.0008214822,0.01104867,0.003562431,0.00006085207,0.003083739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01169385,"threshold_uncertainty_score":0.06184375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08911593254610639,"score_gpt":0.4122735967229011,"score_spread":0.3231576641767948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}