{"id":"W4389303227","doi":"10.1016/j.jacc.2023.10.007","title":"Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials","year":2023,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Discontinuation; Adverse effect; Tolerability; Incidence (geometry); Internal medicine; Placebo; Population; Creatinine; Post-hoc analysis; Hazard ratio; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009693372,0.00009805236,0.003477217,0.0001489607,0.00001901766,6.208149e-7,0.000111115,0.0000767735,9.425747e-7],"category_scores_gemma":[0.002087727,0.00005526908,0.001347746,0.0003391175,0.0004871344,0.00001825977,0.00004336868,0.0001094471,9.339267e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008180182,"about_ca_system_score_gemma":0.0003809248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005259517,"about_ca_topic_score_gemma":0.00001147837,"domain_scores_codex":[0.9957321,0.001735167,0.002029203,0.0001274063,0.000230875,0.0001452608],"domain_scores_gemma":[0.996352,0.001501283,0.001425469,0.0003969796,0.0002421898,0.00008206629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02159166,0.0003422672,0.787896,0.0004454364,0.00296642,0.00007609523,0.0002503183,0.0005844256,0.00516152,0.0001203745,0.000495537,0.18007],"study_design_scores_gemma":[0.008882086,0.008501022,0.9729412,0.000134039,0.0006138943,0.0003460901,0.0006913669,0.0000426301,0.0008410341,0.0002170864,0.006736041,0.00005351691],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965113,0.0006157475,0.000140536,0.001587576,0.0002170405,0.0007154352,0.0001472104,0.00000199857,0.00006311226],"genre_scores_gemma":[0.9968364,0.002295689,0.0004597387,0.00006215223,0.000310121,0.000006554244,0.000001412612,0.000009035172,0.00001884544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1850452,"threshold_uncertainty_score":0.3359549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08911593254610639,"score_gpt":0.4122735967229011,"score_spread":0.3231576641767948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}