{"id":"W4389306433","doi":"10.1038/s41556-023-01274-x","title":"Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment","year":2023,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; University of Toronto","funders":"DOD Prostate Cancer Research Program; Clinical and Translational Science Institute, University of California, Los Angeles; Jonsson Comprehensive Cancer Center; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Stop Cancer; Cancer Research Coordinating Committee; Fonds Wetenschappelijk Onderzoek; National Cancer Institute; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; U.S. Department of Health and Human Services; National Institutes of Health; Prostate Cancer Foundation; Fonds De La Recherche Scientifique - FNRS; U.S. Department of Defense","keywords":"Prostate; Biology; Lineage (genetic); Prostate cancer; Cell biology; Chromatin; Epigenetics; Transcription factor; Cancer research; Endocrinology; Biochemistry; Gene; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001977147,0.0001748545,0.0002980158,0.0002308783,0.00008979381,0.00001776312,0.00005415069,0.0002804212,0.0000549879],"category_scores_gemma":[0.00003999173,0.0001138669,0.0000665621,0.0003665635,0.00006706259,0.00002527002,0.00005886911,0.000239728,0.0001374553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287397,"about_ca_system_score_gemma":0.00008447401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001325431,"about_ca_topic_score_gemma":0.000007690421,"domain_scores_codex":[0.9988387,0.0001235258,0.0001481847,0.0004027054,0.0001257069,0.0003612057],"domain_scores_gemma":[0.9993705,0.0001198816,0.00003844155,0.0002130262,0.00007266659,0.0001855094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01144024,0.0002608978,0.02360942,0.0000589625,0.0001948994,0.000283969,0.001822634,0.000001823028,0.9386935,0.00007652437,0.004795933,0.01876119],"study_design_scores_gemma":[0.005255751,0.001834347,0.202913,0.00002491265,0.0001081185,0.00002189773,0.0001997426,0.00005944587,0.3246489,0.00004403842,0.4647001,0.0001897639],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880651,0.007200126,0.000005750684,0.003054457,0.0003579881,0.000738382,0.0001516571,0.0000855242,0.000340995],"genre_scores_gemma":[0.9850152,0.004867023,0.0001190492,0.0001700776,0.0002716622,0.0000777674,0.0005060087,0.00002131674,0.008951899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6140446,"threshold_uncertainty_score":0.4643356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01736289114010957,"score_gpt":0.3151947303963084,"score_spread":0.2978318392561988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}