{"id":"W4389307256","doi":"10.3390/curroncol30120751","title":"Combining Novel Hormonal Therapies with a Poly (ADP-Ribose) Polymerase Inhibitor for Metastatic Castration-Resistant Prostate Cancer: Emerging Evidence","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"West China Hospital, Sichuan University; Sichuan University; National Key Research and Development Program of China; Jiangsu Development and Reform Commission; National Natural Science Foundation of China","keywords":"Olaparib; Medicine; PARP inhibitor; Prostate cancer; Oncology; Internal medicine; Taxane; Clinical trial; Placebo; BRCA mutation; Poly ADP ribose polymerase; Cancer; Polymerase; Ovarian cancer; Breast cancer; Pathology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005014391,0.0005330022,0.003179333,0.002127045,0.0002006914,0.001861057,0.0009678339,0.001472824,0.004262038],"category_scores_gemma":[0.00623553,0.0003604943,0.003218194,0.002431173,0.0006195253,0.001609003,0.000514841,0.001019936,0.0005758618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007834892,"about_ca_system_score_gemma":0.001585285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007897549,"about_ca_topic_score_gemma":0.003010947,"domain_scores_codex":[0.9981545,0.0006721994,0.0005650999,0.0002321668,0.000320892,0.00005510565],"domain_scores_gemma":[0.9918284,0.005886266,0.001606993,0.0001255461,0.000420296,0.0001325561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005069472,0.0003507536,0.001842012,0.3553244,0.006492734,0.0002082732,0.0001072854,0.0003172646,0.001939246,0.000769819,0.002586185,0.6249924],"study_design_scores_gemma":[0.01480307,0.02826823,0.02504095,0.4981302,0.1097165,0.003549329,0.0008369494,0.001082305,0.004616697,0.003841301,0.3099479,0.0001665393],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002059371,0.9967265,0.000086588,0.0003514166,0.00006850354,0.00006309849,0.00006945383,0.000005479711,0.0005695233],"genre_scores_gemma":[0.02359662,0.9737167,0.0005613321,0.001520731,0.0001947334,0.00009942214,0.0001307602,0.00000475989,0.0001750006],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005014391,"threshold_uncertainty_score":0.02651894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.381377987920487,"score_gpt":0.5228773061164178,"score_spread":0.1414993181959308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}