{"id":"W4389317379","doi":"10.1039/d3sc04116f","title":"A single phosphorylation mechanism in early metabolism – the case of phosphoenolpyruvate","year":2023,"lang":"en","type":"article","venue":"Chemical Science","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"China Scholarship Council; H2020 European Research Council; Agence Nationale de la Recherche; Volkswagen Foundation; Université de Strasbourg; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Mechanism (biology); Phosphorylation; Phosphoenolpyruvate carboxykinase; Chemistry; Metabolism; Biochemistry; Cell biology; Biology; Philosophy; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346497,0.0004703395,0.0005319392,0.0003511802,0.0007738939,0.001131472,0.000697126,0.001580521,0.002068592],"category_scores_gemma":[0.0006647063,0.0003697592,0.0004800864,0.0002375075,0.001395267,0.003428001,0.000991232,0.001473045,0.001160147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006149342,"about_ca_system_score_gemma":0.0006465474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003592539,"about_ca_topic_score_gemma":0.0002315356,"domain_scores_codex":[0.9997424,0.00001834904,0.00001186881,0.0001254561,0.00005006643,0.00005181122],"domain_scores_gemma":[0.9997589,0.00005058661,0.00003351411,0.00007561328,0.00002701379,0.00005434883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004726872,0.0001605159,0.002188986,0.0009885426,0.00008086555,0.002346699,0.0003104775,0.005479792,0.7071553,0.2335502,0.001166902,0.04609899],"study_design_scores_gemma":[0.00008066375,0.0005562026,0.002689924,0.0000953489,0.00006003673,0.003048438,0.0002377526,0.01754351,0.8216793,0.1128625,0.04102697,0.0001193711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7446228,0.01535068,0.183537,0.003997852,0.001829043,0.0002144688,0.0003738106,0.0008764529,0.04919788],"genre_scores_gemma":[0.978467,0.002514983,0.01539029,0.0001345244,0.00006573534,0.00004964865,0.00008165663,0.00003111701,0.003265001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002068592,"threshold_uncertainty_score":0.006920099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450723731862655,"score_gpt":0.2498086192644886,"score_spread":0.235301381945862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}