{"id":"W4389322957","doi":"10.20944/preprints202312.0185.v1","title":"Antibody Dependent Enhancement (ADE) of Infection into Macrophages Validates the Importance of HERV-K102 Particle Production for Pandemic Preparedness","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada","funders":"","keywords":"Innate immune system; Virology; Biology; Antibody-dependent enhancement; Virus; Viral replication; Retrovirus; Immunology; Macrophage; Immunity; Interferon; Pandemic; Immune system; Disease; Infectious disease (medical specialty); Medicine; Coronavirus disease 2019 (COVID-19); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003924368,0.0002618388,0.0002070924,0.00009701646,0.0001312315,0.000256266,0.0001792333,0.0003536085,0.001301045],"category_scores_gemma":[0.0001644186,0.00006798995,0.0002218545,0.00006012592,0.0002491662,0.0002869744,0.0002922261,0.0008495164,0.0003118166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001435414,"about_ca_system_score_gemma":0.00009771364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002888974,"about_ca_topic_score_gemma":0.000236053,"domain_scores_codex":[0.9997947,0.0000539889,0.00001779951,0.00003688478,0.00004248081,0.00005424686],"domain_scores_gemma":[0.9998535,0.00004495059,0.00002078755,0.00003841013,0.00002656898,0.00001575985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002032554,0.000107567,0.0004791766,0.00007251719,0.000005335863,0.00008131273,0.00004025744,0.00009228635,0.995352,0.0005485331,0.00008328683,0.002934339],"study_design_scores_gemma":[0.00001816232,0.001501197,0.002689127,0.000008772769,0.00000750656,0.0003749533,0.00004798413,0.0006114704,0.9908572,0.0002327438,0.003645503,0.00000530562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781371,0.002684116,0.0112637,0.0006164739,0.0001936879,0.0001133287,0.0003895891,0.00009634077,0.006505655],"genre_scores_gemma":[0.9924331,0.0005703812,0.004061273,0.0001437539,0.00002548336,0.00003619851,0.0001798891,0.00001239111,0.002537544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301045,"threshold_uncertainty_score":0.00435245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1083594262912407,"score_gpt":0.3952387629246875,"score_spread":0.2868793366334469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}