{"id":"W4389326973","doi":"10.1001/jamanetworkopen.2023.46094","title":"Liver Metastases and Immune Checkpoint Inhibitor Efficacy in Patients With Refractory Metastatic Colorectal Cancer","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; University of Ottawa; Hôpital du Sacré-Cœur de Montréal; Queen Elizabeth II Health Sciences Centre; Moncton Hospital; Juravinski Cancer Centre; Hôpital Charles-Le Moyne; St. John’s Health Sciences Centre; BC Cancer Agency; Hôtel-Dieu de Québec; Queen's University; Princess Margaret Cancer Centre; Ottawa Hospital","funders":"National Cancer Institute","keywords":"Medicine; Tremelimumab; Durvalumab; Colorectal cancer; Internal medicine; Hazard ratio; Oncology; Microsatellite instability; Clinical endpoint; Cancer; Proportional hazards model; Randomized controlled trial; Immunotherapy; Confidence interval; Nivolumab; Ipilimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002372969,0.0002791859,0.0006672416,0.0002878167,0.0002025425,0.0003180262,0.0002540663,0.000393572,0.001613543],"category_scores_gemma":[0.004245234,0.0001535653,0.0008542422,0.0004001738,0.0002407941,0.0002882292,0.0001817857,0.0006796615,0.0001213465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005398549,"about_ca_system_score_gemma":0.0008266746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001646204,"about_ca_topic_score_gemma":0.004551581,"domain_scores_codex":[0.9991992,0.0004464765,0.00005919065,0.00009761094,0.0001385377,0.00005901715],"domain_scores_gemma":[0.9973935,0.001044555,0.0009275593,0.0001267273,0.0001340227,0.000373715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1926075,0.001236405,0.7487669,0.0007993773,0.00299201,0.0002419168,0.00007977257,0.001642685,0.003939881,0.0001545089,0.001751935,0.04578702],"study_design_scores_gemma":[0.009289705,0.0175414,0.9664111,0.00005872556,0.001487665,0.0003777976,0.00004142394,0.002172605,0.0008207265,0.0001996188,0.00157862,0.0000205996],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941242,0.004064859,0.0001622248,0.0002333383,0.00002616218,0.00007200624,0.0005212045,0.00001114526,0.0007848078],"genre_scores_gemma":[0.9990317,0.0002916569,0.000102571,0.00007504039,0.00003991831,0.0000301796,0.0002611505,0.000001556208,0.0001662459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002372969,"threshold_uncertainty_score":0.01254958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001584258365425,"score_gpt":0.2862240956349806,"score_spread":0.2662082530513263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}