{"id":"W4389326973","doi":"10.1001/jamanetworkopen.2023.46094","title":"Liver Metastases and Immune Checkpoint Inhibitor Efficacy in Patients With Refractory Metastatic Colorectal Cancer","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; University of Ottawa; Hôpital du Sacré-Cœur de Montréal; Queen Elizabeth II Health Sciences Centre; Moncton Hospital; Juravinski Cancer Centre; Hôpital Charles-Le Moyne; St. John’s Health Sciences Centre; BC Cancer Agency; Hôtel-Dieu de Québec; Queen's University; Princess Margaret Cancer Centre; Ottawa Hospital","funders":"National Cancer Institute","keywords":"Medicine; Tremelimumab; Durvalumab; Colorectal cancer; Internal medicine; Hazard ratio; Oncology; Microsatellite instability; Clinical endpoint; Cancer; Proportional hazards model; Randomized controlled trial; Immunotherapy; Confidence interval; Nivolumab; Ipilimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006735833,0.0001875551,0.0004442394,0.00009799822,0.00008435332,0.0000921659,0.0001448539,0.00005623969,0.0003072441],"category_scores_gemma":[0.00004592214,0.0001349381,0.00005637691,0.0007288771,0.0001046375,0.0002423274,0.0001859454,0.0002140923,0.00001899949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001281812,"about_ca_system_score_gemma":0.0001388229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001366862,"about_ca_topic_score_gemma":0.0005011443,"domain_scores_codex":[0.9986259,0.0001274517,0.0003440138,0.0003140293,0.0002403028,0.0003483375],"domain_scores_gemma":[0.9993393,0.0001628795,0.0001429324,0.0002002179,0.00006306632,0.00009162839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08287264,0.00176327,0.5889814,0.0003469272,0.002400453,0.0004352553,0.002470796,0.0003437961,0.002804948,0.00003748105,0.02554002,0.292003],"study_design_scores_gemma":[0.01330874,0.0008971882,0.9757301,0.0007176891,0.0001291467,0.000004641339,0.0001068829,0.0001218292,0.0006831423,0.000007299108,0.008101587,0.0001917321],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943928,0.002988659,0.00000124165,0.0006099181,0.000177058,0.001417801,0.00003655683,0.00004048495,0.0003355457],"genre_scores_gemma":[0.9973482,0.00101636,0.0003360327,0.0003996453,0.0001497666,0.0001690689,0.0001480203,0.000038606,0.0003942446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3867487,"threshold_uncertainty_score":0.5502616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001584258365425,"score_gpt":0.2862240956349806,"score_spread":0.2662082530513263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}