{"id":"W4389328752","doi":"10.1093/humrep/dead247","title":"Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity","year":2023,"lang":"en","type":"review","venue":"Human Reproduction","topic":"Assisted Reproductive Technology and Twin Pregnancy","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"FP7 Health; National Cancer Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; U.S. Public Health Service; Leids Universitair Medisch Centrum; Medical Research Council; Agence Nationale de la Recherche; Versus Arthritis; H2020 European Research Council; Universitair Medisch Centrum Groningen; Vrije Universiteit Amsterdam; Australian Research Council; Universiteit Leiden; King's College London; National Institute on Aging; National Institute for Health and Care Research; National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; National Institute of Mental Health; QIMR Berghofer Medical Research Institute; Horizon 2020 Framework Programme; National Institute on Alcohol Abuse and Alcoholism; Academy of Finland; Broad Institute; Foundation for the National Institutes of Health; Chronic Disease Research Foundation; European Commission; Eunice Kennedy Shriver National Institute of Child Health and Human Development; ZonMw; Amgen","keywords":"Biology; Genetics; Genome-wide association study; Genetic association; Dizygotic twin; Fecundity; Twin study; Fertility; Offspring; Demography; Heritability; Single-nucleotide polymorphism; Gene; Pregnancy; Population; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006909951,0.001055173,0.002956698,0.001930445,0.0007286376,0.001856911,0.001176491,0.000953563,0.002095766],"category_scores_gemma":[0.01291101,0.0006094307,0.008972552,0.003472409,0.0005542017,0.0006863019,0.001041126,0.001346665,0.0002050292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003802378,"about_ca_system_score_gemma":0.0006613242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004034158,"about_ca_topic_score_gemma":0.005337084,"domain_scores_codex":[0.994201,0.002814126,0.0005610882,0.001700735,0.0004595472,0.0002635758],"domain_scores_gemma":[0.9905968,0.005277832,0.001282571,0.00201623,0.0004758025,0.0003509129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002934709,0.00003599968,0.7948226,0.00197494,0.180721,0.0006167989,0.0001903722,0.001091804,0.004580636,0.0005127941,0.001013227,0.01150515],"study_design_scores_gemma":[0.0004018813,0.0004326245,0.7477946,0.0006223241,0.2378565,0.001236461,0.0002932668,0.003977364,0.002215879,0.002123827,0.002995038,0.00005012273],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.875394,0.1022595,0.01428808,0.001895732,0.0005025849,0.0001196591,0.003340285,0.0002124465,0.001987696],"genre_scores_gemma":[0.9919528,0.004751117,0.001871625,0.0002375725,0.0001005731,0.00005206576,0.0007203129,0.00003673727,0.000277089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006909951,"threshold_uncertainty_score":0.03654373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1924804226540351,"score_gpt":0.3915252438907106,"score_spread":0.1990448212366755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}