{"id":"W4389328752","doi":"10.1093/humrep/dead247","title":"Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity","year":2023,"lang":"en","type":"review","venue":"Human Reproduction","topic":"Assisted Reproductive Technology and Twin Pregnancy","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"FP7 Health; National Cancer Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; U.S. Public Health Service; Leids Universitair Medisch Centrum; Medical Research Council; Agence Nationale de la Recherche; Versus Arthritis; H2020 European Research Council; Universitair Medisch Centrum Groningen; Vrije Universiteit Amsterdam; Australian Research Council; Universiteit Leiden; King's College London; National Institute on Aging; National Institute for Health and Care Research; National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; National Institute of Mental Health; QIMR Berghofer Medical Research Institute; Horizon 2020 Framework Programme; National Institute on Alcohol Abuse and Alcoholism; Academy of Finland; Broad Institute; Foundation for the National Institutes of Health; Chronic Disease Research Foundation; European Commission; Eunice Kennedy Shriver National Institute of Child Health and Human Development; ZonMw; Amgen","keywords":"Biology; Genetics; Genome-wide association study; Genetic association; Dizygotic twin; Fecundity; Twin study; Fertility; Offspring; Demography; Heritability; Single-nucleotide polymorphism; Gene; Pregnancy; Population; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002506777,0.0004528522,0.005117823,0.002030458,0.0001794675,0.00001022505,0.000209003,0.0005191556,0.000175039],"category_scores_gemma":[0.002314106,0.0003798963,0.002355755,0.00334786,0.0001827731,0.00007506055,0.0001316372,0.0005570479,0.00002287648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004003339,"about_ca_system_score_gemma":0.0001000141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000556975,"about_ca_topic_score_gemma":0.00002641052,"domain_scores_codex":[0.9950234,0.0006127707,0.001851903,0.001576185,0.0006651796,0.0002705855],"domain_scores_gemma":[0.9933478,0.0002682527,0.003323899,0.002338088,0.0006783581,0.00004366615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0000425714,0.002627424,0.09646639,0.03051299,0.8147554,0.00003928435,0.00153171,0.0003188344,0.0001993629,0.00009568868,0.0000824901,0.05332787],"study_design_scores_gemma":[0.0001783902,0.0003395629,0.3518223,0.0005292457,0.6428083,0.000007274835,0.0002002432,0.000001866541,0.00008056335,0.0001668529,0.003611272,0.0002540732],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05588931,0.9405158,0.00005099926,0.00005007942,0.0002557572,0.002843772,0.00002277427,0.0002428104,0.0001286846],"genre_scores_gemma":[0.2750506,0.7080922,0.0003855291,0.000004451736,0.0005030294,0.0005999506,0.000956039,0.0001825046,0.01422566],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.255356,"threshold_uncertainty_score":0.9998653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1924804226540351,"score_gpt":0.3915252438907106,"score_spread":0.1990448212366755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}