{"id":"W4389332719","doi":"10.1101/2023.12.04.569993","title":"Membrane fusion activity of herpes simplex virus 1 glycoproteins from a hyperfusogenic virus","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Institutes of Health","keywords":"Herpes simplex virus; Herpesvirus glycoprotein B; Cell fusion; Lipid bilayer fusion; Fusion protein; Vero cell; Glycoprotein; Virology; Virus; Viral entry; Biology; Wild type; Fusion gene; Molecular biology; Cell culture; Viral envelope; Gene; Chemistry; Recombinant DNA; Viral replication; Mutant; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025113,0.0002835498,0.0002254948,0.0003000434,0.0001421427,0.000455076,0.0002129064,0.0002270748,0.0007537855],"category_scores_gemma":[0.0003477797,0.0001150483,0.0003212858,0.0003147652,0.000197666,0.0003245905,0.000341113,0.0003763111,0.0002250045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007578676,"about_ca_system_score_gemma":0.0001943617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001714531,"about_ca_topic_score_gemma":0.001058329,"domain_scores_codex":[0.9998003,0.0000503858,0.00001730381,0.00002957992,0.00006888788,0.00003358259],"domain_scores_gemma":[0.9999002,0.00002768631,0.00001867629,0.0000195394,0.00001717494,0.00001670481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001123716,0.000009055418,0.0003872832,0.0000443099,0.000008027752,0.0000431934,0.0000277003,0.00006161262,0.9975721,0.0001963891,0.00003662813,0.001501138],"study_design_scores_gemma":[0.000008509888,0.0001492181,0.00698385,0.00001594034,0.00002108022,0.0005144321,0.00004616228,0.0008691521,0.9860923,0.0001574459,0.005133237,0.000008780758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930172,0.002650079,0.002207918,0.00005909985,0.00003327852,0.00001929067,0.0004561492,0.00003645077,0.001520552],"genre_scores_gemma":[0.9926225,0.001303377,0.002655506,0.00004041499,0.000009189807,0.00001946542,0.001628455,0.00001950623,0.001701448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001714531,"threshold_uncertainty_score":0.005498767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02984541430099179,"score_gpt":0.2620893375951905,"score_spread":0.2322439232941987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}