{"id":"W4389333786","doi":"10.1016/j.ceb.2023.102291","title":"AAA ATPase protein–protein interactions as therapeutic targets in cancer","year":2023,"lang":"en","type":"review","venue":"Current Opinion in Cell Biology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"AAA proteins; Biology; ATPase; Protein family; ATP hydrolysis; Function (biology); Computational biology; Cancer; Enzyme; Cell biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003175873,0.0004771177,0.000867657,0.0004253954,0.00007047385,0.00002331912,0.0005171521,0.0005535954,0.0002195634],"category_scores_gemma":[0.0001032317,0.0004070538,0.0003349463,0.0004918609,0.0001365486,0.000005443028,0.0003852406,0.0008716454,0.0003271436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001703078,"about_ca_system_score_gemma":0.0006926312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002035172,"about_ca_topic_score_gemma":0.0001054508,"domain_scores_codex":[0.9969351,0.0006156475,0.0007397588,0.0009320469,0.0001220027,0.0006554064],"domain_scores_gemma":[0.9989762,0.00006840476,0.000265661,0.0005154646,0.00005666013,0.0001175502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005471554,0.0004123738,0.00007942456,0.01159651,0.00009173434,0.000006640573,0.00002954073,0.00000463372,0.007083229,0.0001248404,0.001021234,0.9794951],"study_design_scores_gemma":[0.0003419968,0.0001829895,0.00000355881,0.005960433,0.00001782187,0.000001931168,0.00001551819,0.000008070447,0.001184449,0.0001703765,0.9916936,0.0004193205],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00110594,0.9944311,0.00005211951,0.00008025393,0.00208517,0.001870079,0.0001906043,0.0000235496,0.0001612286],"genre_scores_gemma":[0.0008115786,0.9922503,0.00001240813,0.00001168041,0.0008722066,0.002932201,0.002057587,0.00008050501,0.0009715033],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9906723,"threshold_uncertainty_score":0.9998381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1795909481499528,"score_gpt":0.4876147696911723,"score_spread":0.3080238215412195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}