{"id":"W4389333938","doi":"10.1038/s41467-023-43904-w","title":"Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada); Feldan (Canada)","funders":"California National Primate Research Center; National Institute of Diabetes and Digestive and Kidney Diseases; Howard Hughes Medical Institute; Roy J. Carver Charitable Trust; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Center for Research Resources; Québec Consortium for Drug Discovery; Institut sur la Nutrition et les Aliments Fonctionnels; National Institutes of Health; U.S. Department of Health and Human Services; National Institute of Environmental Health Sciences; Petroleum Technology Alliance Canada","keywords":"Ribonucleoprotein; Cystic fibrosis; Cell biology; Airway; Respiratory epithelium; In vivo; Biology; Peptide; Molecular biology; Epithelium; Chemistry; RNA; Medicine; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483008,0.0001126857,0.00009261323,0.0001112167,0.00008819004,0.00001520796,0.0006418007,0.0002282198,0.00001630456],"category_scores_gemma":[0.0001320014,0.0001226598,0.00006091689,0.0003307569,0.00002830885,0.000002834148,0.0003924905,0.0003179709,0.0001009629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002228062,"about_ca_system_score_gemma":0.00004114764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004358553,"about_ca_topic_score_gemma":0.001005259,"domain_scores_codex":[0.9992963,0.00004302509,0.0001470873,0.0002052597,0.00009869746,0.0002096423],"domain_scores_gemma":[0.9986551,0.000051748,0.00002250562,0.00111259,0.00006725382,0.00009082524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001357836,0.00003908841,0.0003284681,0.000006592547,0.00001432643,0.000001476358,0.0001456216,0.003525203,0.8303706,0.00007344427,0.1648288,0.0006527664],"study_design_scores_gemma":[0.0002651273,0.00004982967,0.001402937,0.00001395207,0.000008853553,0.000001206295,0.0001892145,0.001190661,0.294472,0.00001033961,0.702211,0.0001848415],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675,0.00450863,0.003489408,0.008009407,0.005578636,0.001117732,0.0010972,0.000249724,0.008449288],"genre_scores_gemma":[0.992848,0.0009275097,0.003896795,0.000291802,0.0006282186,0.00005593639,0.0001781257,0.00002477483,0.001148843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5373822,"threshold_uncertainty_score":0.500192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008324635655184398,"score_gpt":0.2971084681854964,"score_spread":0.288783832530312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}