{"id":"W4389333938","doi":"10.1038/s41467-023-43904-w","title":"Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada); Feldan (Canada)","funders":"California National Primate Research Center; National Institute of Diabetes and Digestive and Kidney Diseases; Howard Hughes Medical Institute; Roy J. Carver Charitable Trust; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Center for Research Resources; Québec Consortium for Drug Discovery; Institut sur la Nutrition et les Aliments Fonctionnels; National Institutes of Health; U.S. Department of Health and Human Services; National Institute of Environmental Health Sciences; Petroleum Technology Alliance Canada","keywords":"Ribonucleoprotein; Cystic fibrosis; Cell biology; Airway; Respiratory epithelium; In vivo; Biology; Peptide; Molecular biology; Epithelium; Chemistry; RNA; Medicine; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002994838,0.0003107542,0.0002977537,0.0001721059,0.0002544233,0.0004436562,0.0002297066,0.0006346729,0.00159931],"category_scores_gemma":[0.0001713677,0.0001677108,0.0002495169,0.00009618144,0.0002777644,0.000182495,0.0002301071,0.0005732034,0.0006683835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889153,"about_ca_system_score_gemma":0.0003123668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001751174,"about_ca_topic_score_gemma":0.001991407,"domain_scores_codex":[0.9997662,0.00004243599,0.00001453774,0.00007277081,0.00005983595,0.0000442682],"domain_scores_gemma":[0.9998862,0.00003094095,0.00002364091,0.00002339978,0.00001212752,0.00002376609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003167273,0.00001199702,0.00007190263,0.00001624148,0.000003163486,0.00008795708,0.00002585332,0.00005862223,0.9985265,0.0001112401,0.00006875558,0.0009860233],"study_design_scores_gemma":[0.000007215412,0.0002040208,0.0006826163,0.000003870243,0.000008120331,0.0002814181,0.00002751157,0.0009008615,0.9929842,0.00003950216,0.004856395,0.000004244029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754989,0.002108755,0.01435932,0.0004114114,0.0001649227,0.0001404006,0.0008179283,0.0004557389,0.006042609],"genre_scores_gemma":[0.9824709,0.001117483,0.008371993,0.0001408441,0.00002482173,0.00007963973,0.0004729982,0.0001187423,0.007202488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001751174,"threshold_uncertainty_score":0.005350232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008324635655184398,"score_gpt":0.2971084681854964,"score_spread":0.288783832530312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}