{"id":"W4389336268","doi":"10.3390/vaccines11121819","title":"Intensified Influenza Virus Production in Suspension HEK293SF Cell Cultures Operated in Fed-Batch or Perfusion with Continuous Harvest","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Perfusion; Bioreactor; Pulp and paper industry; Continuous production; Process engineering; Environmental science; Biotechnology; Food science; Chemistry; Biology; Environmental engineering; Medicine; Botany; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002449987,0.0004055577,0.0003645364,0.0001398121,0.0001386877,0.000424394,0.0003054931,0.0003058483,0.0005865428],"category_scores_gemma":[0.0001294758,0.0001260045,0.0003109779,0.0001677669,0.0001729186,0.0003040449,0.0002259771,0.0006793435,0.0003124001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002971157,"about_ca_system_score_gemma":0.0001901268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007078423,"about_ca_topic_score_gemma":0.0009859035,"domain_scores_codex":[0.9998639,0.00001574428,0.00001476505,0.00004342189,0.00004167686,0.00002041166],"domain_scores_gemma":[0.9999341,0.00001883459,0.00001752155,0.000008440189,0.00001180098,0.000009305562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002460859,0.00001515791,0.00007458522,0.00001927774,0.000001613827,0.00001370159,0.000009517154,0.00005502774,0.9991159,0.00002271662,0.00001474726,0.0006330636],"study_design_scores_gemma":[0.000005113834,0.0001636654,0.001210028,0.000003697363,0.000007962532,0.00004902976,0.000009771336,0.001326789,0.9965577,0.00001690556,0.0006437171,0.000005645177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826278,0.000498357,0.01463525,0.00005102396,0.00003839389,0.00009174692,0.0006196309,0.0001763996,0.001261301],"genre_scores_gemma":[0.9450145,0.0009750248,0.0492176,0.00006498135,0.00001964959,0.0001925481,0.001368019,0.00008834228,0.003059472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007078423,"threshold_uncertainty_score":0.002155721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0153432375850127,"score_gpt":0.2790569136133497,"score_spread":0.263713676028337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}