{"id":"W4389336268","doi":"10.3390/vaccines11121819","title":"Intensified Influenza Virus Production in Suspension HEK293SF Cell Cultures Operated in Fed-Batch or Perfusion with Continuous Harvest","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Perfusion; Bioreactor; Pulp and paper industry; Continuous production; Process engineering; Environmental science; Biotechnology; Food science; Chemistry; Biology; Environmental engineering; Medicine; Botany; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376769,0.0002054176,0.0002033938,0.0001524558,0.00009475544,0.00005121848,0.0001113918,0.0001527031,0.00003563142],"category_scores_gemma":[0.0001801757,0.0001382487,0.00004023516,0.0005731307,0.00002159868,0.00001645885,0.0001127879,0.0001260174,0.00003165947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001905234,"about_ca_system_score_gemma":0.00005903605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006905472,"about_ca_topic_score_gemma":0.006863869,"domain_scores_codex":[0.9987639,0.00008689114,0.0002646308,0.0004996092,0.00010995,0.0002749983],"domain_scores_gemma":[0.9993955,0.000009910141,0.00007343067,0.0002830446,0.0001727348,0.00006534261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001872121,0.0001585626,0.03937215,0.00003535922,0.000007317979,0.00004513189,0.0001539362,0.002216215,0.9377725,0.000001423403,0.01791642,0.0004488869],"study_design_scores_gemma":[0.002136199,0.0008751808,0.1023591,0.0001452748,0.00001045252,0.00002962621,0.0007805912,0.0002186679,0.8850294,0.00001627979,0.008038042,0.0003612202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985111,0.0003179959,0.000003096459,0.000185957,0.0003739436,0.0003995702,0.000007065451,0.00005515564,0.0001460529],"genre_scores_gemma":[0.996153,0.0004802725,0.00003230196,0.0003132535,0.0001892114,0.00006683228,0.00013857,0.00003027885,0.002596305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06298693,"threshold_uncertainty_score":0.5637619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0153432375850127,"score_gpt":0.2790569136133497,"score_spread":0.263713676028337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}