{"id":"W4389336717","doi":"10.3390/cells12242771","title":"Single-Cell Sequencing of Lung Macrophages and Monocytes Reveals Novel Therapeutic Targets in COPD","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital; National Research Council Canada; Simon Fraser University; University of Saskatchewan; University of Victoria","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"COPD; Monocyte; Cell; Lung; Macrophage; Medicine; Computational biology; Biology; Immunology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452238,0.0001251109,0.0001653114,0.00006178734,0.0000299961,0.0000141292,0.000106287,0.000114041,0.000007387022],"category_scores_gemma":[0.00001063011,0.0001231414,0.00004672729,0.0001303517,0.00006634582,0.000003404107,0.00004587201,0.00006509614,0.000003845046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001626518,"about_ca_system_score_gemma":0.0000296073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003267364,"about_ca_topic_score_gemma":0.00001781616,"domain_scores_codex":[0.9992323,0.00002834426,0.0002062726,0.0002458393,0.000069893,0.0002173457],"domain_scores_gemma":[0.9996718,0.00002886771,0.00005989655,0.0001661843,0.00003028192,0.00004303637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002638406,0.00005026657,0.003948604,0.000107342,0.00001380109,0.000004648192,0.000215907,0.0001417977,0.9947174,0.000008549863,0.0001747959,0.0005905043],"study_design_scores_gemma":[0.000572442,0.00009793743,0.001453675,0.00002761648,0.00001183937,0.000001995437,0.0001055308,0.0006062074,0.9961085,0.00004267007,0.0008339749,0.0001376334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948152,0.003648929,0.0005976369,0.00002562623,0.0001369382,0.0001432476,0.00002153572,0.00001408816,0.000596799],"genre_scores_gemma":[0.9979687,0.0005090547,0.0004785914,0.0001164909,0.00004721017,0.000005207227,0.00003249488,0.00002378061,0.0008185054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003153465,"threshold_uncertainty_score":0.502156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02449645901718386,"score_gpt":0.2386354328154272,"score_spread":0.2141389737982433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}