{"id":"W4389336717","doi":"10.3390/cells12242771","title":"Single-Cell Sequencing of Lung Macrophages and Monocytes Reveals Novel Therapeutic Targets in COPD","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital; National Research Council Canada; Simon Fraser University; University of Saskatchewan; University of Victoria","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"COPD; Monocyte; Cell; Lung; Macrophage; Medicine; Computational biology; Biology; Immunology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003600236,0.0002344423,0.0005385245,0.0003248215,0.0001856697,0.0003796807,0.0001536097,0.000356425,0.001181577],"category_scores_gemma":[0.000336221,0.0001220065,0.0004386032,0.0003489376,0.0001568271,0.0001253031,0.0001910624,0.0003155232,0.0003958485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236182,"about_ca_system_score_gemma":0.0003255491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002917234,"about_ca_topic_score_gemma":0.0006114746,"domain_scores_codex":[0.9997934,0.00003228109,0.00001284504,0.00005513741,0.000073346,0.00003313336],"domain_scores_gemma":[0.9998295,0.00006207607,0.00003320146,0.00001424742,0.00003884733,0.00002204787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001866957,0.0001051551,0.01808986,0.0005487039,0.00009808678,0.0001135424,0.00006956296,0.00131825,0.9497365,0.0001639197,0.0006581575,0.0272313],"study_design_scores_gemma":[0.0002720686,0.002508091,0.2188555,0.0001536363,0.0007251995,0.001071982,0.0003767009,0.02068747,0.7385934,0.001327657,0.01538443,0.00004396693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753179,0.007572409,0.0103003,0.0003014775,0.00006134432,0.0000939835,0.005000541,0.0001547379,0.001197213],"genre_scores_gemma":[0.9708774,0.003081588,0.01588046,0.0004865895,0.0000476011,0.000256937,0.007860863,0.00006204163,0.001446499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181577,"threshold_uncertainty_score":0.003952742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02449645901718386,"score_gpt":0.2386354328154272,"score_spread":0.2141389737982433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}