{"id":"W4389338800","doi":"10.1038/s42003-023-05624-1","title":"Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels","year":2023,"lang":"en","type":"article","venue":"Communications Biology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; U.S. Department of Health and Human Services; National Cancer Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","keywords":"TRPV1; Bortezomib; Sensitization; Pharmacology; Chemistry; In vivo; Medicine; Transient receptor potential channel; Immunology; Internal medicine; Multiple myeloma; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268553,0.0004132791,0.0004171696,0.0002397847,0.000171245,0.0002130234,0.00009998855,0.0001693326,0.001839929],"category_scores_gemma":[0.00009033904,0.0001595359,0.0002823817,0.0002468751,0.0001464459,0.000185583,0.0001709121,0.0003266332,0.0003075712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002824161,"about_ca_system_score_gemma":0.0002081485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003656949,"about_ca_topic_score_gemma":0.001219598,"domain_scores_codex":[0.9998797,0.00001406376,0.00001141846,0.00002385459,0.00004191433,0.00002896816],"domain_scores_gemma":[0.9999529,0.000009455554,0.00001896284,0.000003685571,0.000006445232,0.000008560984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007651526,0.00002200093,0.0004267772,0.00009578629,0.000007812017,0.00006148145,0.000006058794,0.0000993664,0.9961112,0.00002819318,0.00005012651,0.003014765],"study_design_scores_gemma":[0.00005912146,0.002316138,0.03672851,0.0000356401,0.00004465106,0.001369873,0.00004793907,0.0004477197,0.9526153,0.0001370364,0.006184905,0.00001315699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790354,0.01072721,0.004164115,0.0002406767,0.00004609277,0.0001325586,0.001353046,0.0001884503,0.004112512],"genre_scores_gemma":[0.984633,0.009084359,0.002910558,0.0001952153,0.00001857432,0.00008279808,0.001188123,0.00001940144,0.001868015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839929,"threshold_uncertainty_score":0.006155193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1062533832339357,"score_gpt":0.3310914227951814,"score_spread":0.2248380395612457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}