{"id":"W4389341139","doi":"10.5772/intechopen.113912","title":"Founder Effect: Breeding a Dog for the Elderly Gentleman Reveals an Animal Model of a Human Genetic Disorder","year":2023,"lang":"en","type":"book-chapter","venue":"Genetics.","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Breed; Biology; Population; Genetics; Population bottleneck; Allele; Genotyping; Founder effect; Mutation; Gene; Genotype; Demography; Microsatellite; Haplotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003756988,0.0005699981,0.0005539011,0.000111989,0.0002693078,0.00006796949,0.0007210087,0.0005751717,0.0000368233],"category_scores_gemma":[0.00004061061,0.0004843807,0.0004644876,0.00004143537,0.0001981904,0.000002824591,0.0004138268,0.0002070406,0.00001377729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001855157,"about_ca_system_score_gemma":0.00009298215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002138981,"about_ca_topic_score_gemma":0.0001229148,"domain_scores_codex":[0.9975112,0.00003286801,0.000684876,0.0008698628,0.0003387931,0.0005624119],"domain_scores_gemma":[0.9980756,0.00006067053,0.0004032964,0.001107518,0.0002113893,0.0001415288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005163254,0.00007515186,0.001076953,0.0006860955,0.0008966897,0.000002744619,0.000203377,0.004960807,0.9572411,0.002494281,0.002263799,0.03004739],"study_design_scores_gemma":[0.02927892,0.1805456,0.05774609,0.003498826,0.01416878,0.0007679574,0.001237517,0.1602864,0.1753235,0.1685705,0.1869595,0.02161634],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710346,0.005073463,0.01206372,0.0001291158,0.0004966849,0.002893826,0.0002986932,0.00006195061,0.007947954],"genre_scores_gemma":[0.8966044,0.001066101,0.004310888,0.00009386515,0.0009745286,0.000229835,0.0003193151,0.0004522195,0.09594887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7819176,"threshold_uncertainty_score":0.9997608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03272385351567018,"score_gpt":0.283637738525617,"score_spread":0.2509138850099468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}