{"id":"W4389342183","doi":"10.1002/alz.13559","title":"Tau‐neurodegeneration <i>mismatch</i> reveals vulnerability and resilience to comorbidities in Alzheimer's continuum","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Lunds Universitet; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; University of Southern California; BioClinica; Bristol-Myers Squibb; Eli Lilly and Company; Biogen","keywords":"Neurodegeneration; Cohort; Neuroscience; Alzheimer's disease; Medicine; Psychology; Disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00087322,0.0003757331,0.0003012645,0.0007539141,0.0003398615,0.000480259,0.0002404814,0.0002341311,0.001096513],"category_scores_gemma":[0.002253333,0.00009884205,0.0003610915,0.0004439117,0.0005155882,0.0003141905,0.0005448514,0.0002387003,0.0002014343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479652,"about_ca_system_score_gemma":0.0002516624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002511678,"about_ca_topic_score_gemma":0.00309596,"domain_scores_codex":[0.9998078,0.00005290185,0.00002495605,0.00006802288,0.00002334129,0.00002304156],"domain_scores_gemma":[0.9992388,0.0002009333,0.000310483,0.0001073379,0.00005245389,0.0000899763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001045535,0.0000396443,0.9821066,0.00002248041,0.0001270117,0.0002175505,0.0002052316,0.001881313,0.007265034,0.0001092261,0.00008089148,0.006899554],"study_design_scores_gemma":[0.00001438414,0.0002252189,0.9907315,0.000008610557,0.00005922915,0.0007291451,0.0002391449,0.005328419,0.001763725,0.0007748358,0.0001166745,0.000009019623],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999201,0.00003474005,0.0005145027,0.000011276,7.105451e-7,0.000003384881,0.0000728588,0.000006299029,0.0001552092],"genre_scores_gemma":[0.9996141,0.000008421989,0.0002477716,0.000004088321,0.000001048139,0.000002209142,0.00009441986,0.00000193306,0.00002590605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002511678,"threshold_uncertainty_score":0.004994094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04052143342147348,"score_gpt":0.3310679459039996,"score_spread":0.2905465124825261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}