{"id":"W4389345548","doi":"10.3389/fcell.2023.1282273","title":"Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wolfson Family Charitable Trust; Israel Science Foundation; United States-Israel Binational Science Foundation; Manitoba Liquor and Lotteries","keywords":"Neural tube; Neural plate; Retinoic acid; Neural development; Biology; Wnt signaling pathway; Cell biology; Neural stem cell; Neurulation; Gastrulation; Signal transduction; Biochemistry; Embryogenesis; Embryo; Stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005502438,0.0003954144,0.0001643662,0.0002694386,0.0001151028,0.000151687,0.0001769063,0.0001546803,0.002235016],"category_scores_gemma":[0.00006607678,0.0001154052,0.0002496078,0.00008732494,0.0001987483,0.0001253717,0.000193136,0.0002951352,0.0003659501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003227071,"about_ca_system_score_gemma":0.0002365983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001240576,"about_ca_topic_score_gemma":0.001934349,"domain_scores_codex":[0.9999245,0.00001104686,0.000009671227,0.00001628246,0.0000235285,0.00001498549],"domain_scores_gemma":[0.9999076,0.00001026586,0.00003528811,0.000011408,0.00001265581,0.00002274928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007668797,0.00001275626,0.0002496467,0.00002871193,0.000004457603,0.00004427689,0.000005232796,0.00002190206,0.9987283,0.00002827056,0.00002292614,0.0007769566],"study_design_scores_gemma":[0.000008502773,0.0001590902,0.00472517,0.000005142008,0.0000167605,0.0001404439,0.00001156032,0.0001611348,0.9932001,0.00001840399,0.001551177,0.000002441353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929431,0.001588203,0.002279299,0.0001093767,0.00003078876,0.0000368619,0.0006504905,0.0001699102,0.002191992],"genre_scores_gemma":[0.9904883,0.001572667,0.002184789,0.00005071255,0.00000896919,0.00003029401,0.0008813113,0.00003619996,0.004746806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002235016,"threshold_uncertainty_score":0.007476926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01000987824556997,"score_gpt":0.2270581729222003,"score_spread":0.2170482946766303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}