{"id":"W4389366364","doi":"10.1212/wnl.98.18_supplement.652","title":"A multicentre, open label, single-arm, phase 3b study (CONSONANCE) to assess the effectiveness and safety of ocrelizumab in patients with primary and secondary progressive multiple sclerosis: year-1 interim analysis (P1-1.Virtual)","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"","keywords":"Ocrelizumab; Medicine; Multiple sclerosis; Interim analysis; Relapsing remitting; Interim; Open label; Physical therapy; Pediatrics; Adverse effect; Internal medicine; Clinical trial; Rituximab; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006177434,0.001789441,0.002195631,0.0003861045,0.0006933772,0.001184244,0.001324486,0.002178902,0.005049289],"category_scores_gemma":[0.00293881,0.0006920228,0.002257564,0.0004609107,0.0009405758,0.001164775,0.0006062511,0.00391192,0.001439864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009164508,"about_ca_system_score_gemma":0.002668131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009916878,"about_ca_topic_score_gemma":0.003246036,"domain_scores_codex":[0.9985961,0.0007839905,0.00006528186,0.0002334407,0.0001389895,0.0001821169],"domain_scores_gemma":[0.9978848,0.0003349445,0.0005047324,0.0003086493,0.00021445,0.0007523429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9030034,0.01986656,0.006331682,0.0008214582,0.002084917,0.0001289044,0.0001773912,0.0007986958,0.01710506,0.0004183865,0.00824721,0.04101643],"study_design_scores_gemma":[0.8322796,0.1537507,0.009568986,0.00003105786,0.000449361,0.0001312214,0.00002446957,0.0003298705,0.0008308491,0.0001636529,0.002410576,0.00002975904],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611716,0.004558001,0.00197025,0.001323738,0.0005030221,0.0136232,0.01001735,0.0003376747,0.006495077],"genre_scores_gemma":[0.9529071,0.001415843,0.01002189,0.003430336,0.0005787204,0.01280655,0.01417057,0.0001179154,0.004551103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006177434,"threshold_uncertainty_score":0.03266984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0350482720461275,"score_gpt":0.3025744136992918,"score_spread":0.2675261416531644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}