{"id":"W4389366487","doi":"10.1212/wnl.98.18_supplement.2824","title":"A Phase 2, Randomized, Double-Blind, Placebo-Controlled, 48-Week Study of the Efficacy and Safety of Losmapimod in Subjects with FSHD: ReDUX4 (S23.007)","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; McGill University","funders":"","keywords":"Placebo; Double blind; Medicine; Phase (matter); Internal medicine; Physical therapy; Physics; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001361077,0.002018342,0.002371917,0.0006368695,0.0005954902,0.0007604618,0.0009536694,0.002323714,0.008621716],"category_scores_gemma":[0.001217445,0.0008783328,0.001011334,0.0003424372,0.001069571,0.001072738,0.000301904,0.003005593,0.001478159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000637914,"about_ca_system_score_gemma":0.001263636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009021346,"about_ca_topic_score_gemma":0.00235498,"domain_scores_codex":[0.9996341,0.0001543353,0.00002035607,0.00008199335,0.00004022695,0.00006885712],"domain_scores_gemma":[0.9992748,0.0001605938,0.0001340586,0.00005496018,0.00006139414,0.0003142599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9472401,0.02352592,0.0004503442,0.0005037179,0.0005641709,0.00006082685,0.00005955259,0.0002907666,0.01105502,0.0001247541,0.001444136,0.01468053],"study_design_scores_gemma":[0.9270241,0.07020415,0.001106787,0.00001241,0.0001184879,0.00002566638,0.00001239613,0.0001761234,0.0006926819,0.00008958313,0.000525168,0.00001236473],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750153,0.003498989,0.001641691,0.0008332572,0.0005858019,0.01136715,0.002894844,0.0003614439,0.003801584],"genre_scores_gemma":[0.9638607,0.002688582,0.004014299,0.002488621,0.0006732384,0.01425553,0.002728894,0.00008596855,0.009204123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008621716,"threshold_uncertainty_score":0.02884251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691998127165562,"score_gpt":0.2615001571145037,"score_spread":0.2445801758428481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}