{"id":"W4389366647","doi":"10.1212/wnl.98.18_supplement.2674","title":"Effects of Evobrutinib, a Bruton’s Tyrosine Kinase Inhibitor, on Slowly Expanding Lesions: An Emerging Imaging Marker of Chronic Tissue Loss in Multiple Sclerosis (S14.009)","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeuroRx Research (Canada)","funders":"","keywords":"Multiple sclerosis; Medicine; Pathology; Bruton's tyrosine kinase; Tyrosine-kinase inhibitor; Tyrosine kinase; Internal medicine; Immunology; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001103148,0.0008999368,0.001474005,0.000287447,0.0002753545,0.0007547918,0.0004642938,0.0009665351,0.005670967],"category_scores_gemma":[0.0008344977,0.0002797604,0.0009873125,0.0002338784,0.0004730819,0.0008945462,0.0002264624,0.002837218,0.0008902085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005378241,"about_ca_system_score_gemma":0.000613566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007655877,"about_ca_topic_score_gemma":0.002593661,"domain_scores_codex":[0.9997194,0.00012406,0.00001853709,0.00004480463,0.00002389443,0.00006920231],"domain_scores_gemma":[0.999564,0.0001078649,0.00009542344,0.00002774127,0.00003910848,0.0001658705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8620069,0.01286412,0.001745338,0.001057653,0.001773954,0.00009663901,0.00008745441,0.001088644,0.01327338,0.0002821407,0.004394545,0.1013292],"study_design_scores_gemma":[0.7034225,0.2691856,0.01270961,0.0002042541,0.001341619,0.0002692146,0.00009080887,0.001656416,0.00535243,0.0007187242,0.005003086,0.0000456741],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826293,0.008884035,0.0003211382,0.0009678651,0.0003466261,0.0008285325,0.001229672,0.0001167447,0.00467621],"genre_scores_gemma":[0.9897447,0.002390434,0.0008338265,0.0008067931,0.000182239,0.0008004589,0.001344764,0.00002323107,0.003873527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005670967,"threshold_uncertainty_score":0.01897126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745601822748322,"score_gpt":0.3044620112596024,"score_spread":0.2770059930321191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}