{"id":"W4389368643","doi":"10.1056/nejmc2300400","title":"Tominersen in Adults with Manifest Huntington’s Disease","year":2023,"lang":"en","type":"letter","venue":"New England Journal of Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Wellcome Trust; Roche","keywords":"Huntington's disease; Disease; Psychology; History; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000317663,0.0003843055,0.0006633649,0.0006290768,0.00004336509,0.00002853224,0.000524681,0.0001196727,0.0001519629],"category_scores_gemma":[0.002449166,0.0002433721,0.00009286244,0.0004419378,0.000195828,0.00009213876,0.00005525839,0.001537399,0.0000305039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005654211,"about_ca_system_score_gemma":0.0004317416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007491736,"about_ca_topic_score_gemma":0.00007816994,"domain_scores_codex":[0.9967774,0.0003744653,0.000710145,0.000458137,0.001251401,0.0004284797],"domain_scores_gemma":[0.9976655,0.000813572,0.0006556418,0.0003382181,0.0001342855,0.0003928382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001102892,0.00004438882,0.003459716,0.0002413941,0.00001764321,0.02306964,0.0004939068,0.000179499,0.002389068,0.000008854369,0.9653945,0.003598489],"study_design_scores_gemma":[0.09373989,0.003726725,0.02637218,0.01056833,0.0006457968,0.001491915,0.0002200076,0.0001045209,0.007986704,0.0006985157,0.8532766,0.001168869],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3855109,0.0001933716,0.00001792738,0.6117998,0.001542451,0.0002859233,0.00002946943,0.00002989244,0.0005902129],"genre_scores_gemma":[0.4411775,0.0007901349,0.00009205264,0.4985183,0.05173389,0.00001178432,0.0000444595,0.0002075067,0.007424303],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1132815,"threshold_uncertainty_score":0.9924425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519873195880794,"score_gpt":0.2606002910088506,"score_spread":0.2354015590500426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}