{"id":"W4389372931","doi":"10.2139/ssrn.4653171","title":"RPL22 Is a Tumor Suppressor in MSI-High Cancers and a Key Splicing Regulator of MDM4","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Regulator; Suppressor; Key (lock); RNA splicing; Cancer research; Alternative splicing; Biology; Cancer; Genetics; Gene; Exon; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386775,0.000484618,0.0004528793,0.0004399006,0.0002610034,0.0007265799,0.0002208873,0.0005530777,0.005734769],"category_scores_gemma":[0.0002225288,0.0002476894,0.0002471322,0.0003512371,0.0002570591,0.0001843624,0.0002707183,0.0004848096,0.002333472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177189,"about_ca_system_score_gemma":0.0001011912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001555371,"about_ca_topic_score_gemma":0.0001268647,"domain_scores_codex":[0.9998637,0.00001701343,0.000009152135,0.00004721535,0.0000421668,0.0000205928],"domain_scores_gemma":[0.9998791,0.00002228199,0.00003607926,0.00001596178,0.000009819351,0.00003673329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005851328,0.00002456356,0.00322219,0.00006118534,0.00003795104,0.001575307,0.0000213841,0.0002669419,0.9873793,0.0005304053,0.00083344,0.005462137],"study_design_scores_gemma":[0.00007151427,0.0002328399,0.05212288,0.00001163069,0.00007599251,0.008793199,0.00007904126,0.003028006,0.9190344,0.001528116,0.01500114,0.00002111939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982433,0.004109321,0.005637576,0.0006189219,0.0002143311,0.00001267009,0.001710909,0.000536693,0.004726675],"genre_scores_gemma":[0.9896455,0.0007262712,0.001663638,0.0001038951,0.0000799087,0.00001267043,0.002227486,0.0001200464,0.005420645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005734769,"threshold_uncertainty_score":0.01918471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015628352529224,"score_gpt":0.2717263253698612,"score_spread":0.2615700418445689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}