{"id":"W4389373854","doi":"10.1212/wnl.98.18_supplement.2056","title":"Primary Results of NOVA: a Randomized Controlled Study of the Efficacy of 6 - Week Dosing of Natalizumab Versus Continued 4-Week Treatment for Multiple Sclerosis (S14.005)","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada); Montreal Neurological Institute and Hospital","funders":"","keywords":"Natalizumab; Medicine; Dosing; Randomized controlled trial; Multiple sclerosis; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004913636,0.003224896,0.006232432,0.0007395895,0.001026178,0.00174956,0.00164951,0.003364174,0.01296444],"category_scores_gemma":[0.005787675,0.001004113,0.00529419,0.0004989409,0.001404575,0.001420152,0.0007217196,0.005272846,0.002518776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009949963,"about_ca_system_score_gemma":0.001449503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001665892,"about_ca_topic_score_gemma":0.003555365,"domain_scores_codex":[0.997466,0.001487416,0.0002152743,0.0003823754,0.0001905781,0.0002584085],"domain_scores_gemma":[0.995917,0.001641121,0.0009349516,0.0002912091,0.0003977227,0.0008179655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9905192,0.002035667,0.000197553,0.0007830235,0.002110689,0.00001629523,0.00001483788,0.00008615336,0.0006617307,0.00006065116,0.0005416117,0.002972576],"study_design_scores_gemma":[0.9744785,0.02152026,0.001226238,0.00006244708,0.001739671,0.00001455581,0.00001103104,0.0001431144,0.0002372133,0.0001066192,0.0004468236,0.00001347419],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9058777,0.0235021,0.003980985,0.002644004,0.004450429,0.02782149,0.01667275,0.0007927686,0.01425765],"genre_scores_gemma":[0.9430422,0.006396698,0.00641515,0.003565827,0.002123845,0.01901173,0.006812146,0.0001501949,0.01248229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01296444,"threshold_uncertainty_score":0.04337031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04025906190310468,"score_gpt":0.2584303348545819,"score_spread":0.2181712729514773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}