{"id":"W4389374282","doi":"10.1212/wnl.98.18_supplement.415","title":"Phase 2b Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults with Focal Epilepsy (X-TOLE) (P12-8.006)","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Epilepsy; Potassium channel opener; Medicine; Internal medicine; Potassium channel; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006658806,0.0007887126,0.0008185686,0.0001865809,0.0001857482,0.0005203818,0.0004356384,0.0009363337,0.005425358],"category_scores_gemma":[0.0005409435,0.000292622,0.0005510051,0.0001693119,0.0004353028,0.0006164587,0.0002081221,0.002003817,0.001105637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006740784,"about_ca_system_score_gemma":0.0008476143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000988661,"about_ca_topic_score_gemma":0.002468637,"domain_scores_codex":[0.9997966,0.00008045496,0.00001118493,0.00003384166,0.00002377543,0.00005428618],"domain_scores_gemma":[0.9997333,0.00003803196,0.00006354999,0.00002073987,0.00002868892,0.0001157124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6283638,0.04848095,0.006126205,0.001074927,0.001152331,0.0003505166,0.0002877427,0.002102875,0.1083441,0.0007887327,0.01269493,0.1902327],"study_design_scores_gemma":[0.4279957,0.5213687,0.02139167,0.0000942035,0.0005023073,0.0007517562,0.00009956498,0.00119252,0.01500301,0.0005738728,0.01097796,0.00004884958],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867103,0.002580141,0.0009208133,0.0006384571,0.0001173631,0.002231493,0.003064505,0.0001775579,0.003559284],"genre_scores_gemma":[0.9821639,0.002023823,0.001652774,0.001260912,0.0001008527,0.002437285,0.003795317,0.0000551183,0.006510064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005425358,"threshold_uncertainty_score":0.01814967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004501801434975,"score_gpt":0.2363089946660601,"score_spread":0.2262639766517103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}