{"id":"W4389384383","doi":"10.1016/j.ebiom.2023.104906","title":"CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation","year":2023,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Diabetesförbundet; Stiftelsen Familjen Ernfors Fond; Novo Nordisk; Canada Research Chairs; Novo Nordisk Fonden; Canada Foundation for Innovation; Canadian Blood Services; Canadian Institutes of Health Research; Svenska Diabetesstiftelsen; U.S. Department of Veterans Affairs","keywords":"Insulin resistance; Adipose tissue; Internal medicine; Insulin receptor; Endocrinology; Autophosphorylation; Insulin; Adipocyte; Biology; GLUT4; White adipose tissue; Glucose homeostasis; Cell biology; Phosphorylation; Medicine; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179603,0.0004618019,0.0002465023,0.0002313169,0.0001305703,0.0003758807,0.0003125083,0.0003355935,0.004262339],"category_scores_gemma":[0.0001423094,0.0001078632,0.0002694386,0.00009878071,0.0003233961,0.0001832844,0.0002087117,0.0007634072,0.0006777311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958179,"about_ca_system_score_gemma":0.0001079831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001334965,"about_ca_topic_score_gemma":0.0001531039,"domain_scores_codex":[0.9999046,0.00001459568,0.000007347939,0.00002581019,0.00002667168,0.0000209178],"domain_scores_gemma":[0.9998899,0.00001235989,0.00003942892,0.000008836344,0.00000987106,0.00003954457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000508312,0.00005676128,0.0005954675,0.0001320214,0.00001003083,0.0002696302,0.000008067662,0.0000635781,0.994927,0.0002291137,0.000261076,0.002938796],"study_design_scores_gemma":[0.0001636041,0.0009755835,0.01882712,0.00005679302,0.00008227299,0.001817171,0.00007768825,0.001080501,0.9665908,0.0002813075,0.01003143,0.00001567118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885372,0.003568492,0.003333029,0.0005066957,0.0001771235,0.00003020549,0.000383323,0.0002415428,0.003222301],"genre_scores_gemma":[0.9930067,0.001751535,0.001737884,0.0001755276,0.00006759302,0.00004843503,0.0003182734,0.00003341403,0.002860538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004262339,"threshold_uncertainty_score":0.01425892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013170786767824,"score_gpt":0.2771926940125205,"score_spread":0.2570609861448422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}