{"id":"W4389384383","doi":"10.1016/j.ebiom.2023.104906","title":"CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation","year":2023,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Diabetesförbundet; Stiftelsen Familjen Ernfors Fond; Novo Nordisk; Canada Research Chairs; Novo Nordisk Fonden; Canada Foundation for Innovation; Canadian Blood Services; Canadian Institutes of Health Research; Svenska Diabetesstiftelsen; U.S. Department of Veterans Affairs","keywords":"Insulin resistance; Adipose tissue; Internal medicine; Insulin receptor; Endocrinology; Autophosphorylation; Insulin; Adipocyte; Biology; GLUT4; White adipose tissue; Glucose homeostasis; Cell biology; Phosphorylation; Medicine; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008609745,0.0002828453,0.0004512535,0.0003877871,0.000341753,0.00004247257,0.0001728533,0.0001281572,0.0001592417],"category_scores_gemma":[0.001779913,0.0001987455,0.00005562982,0.001828614,0.00009737695,0.0001672927,0.00008941133,0.0002339299,0.0003907549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007521217,"about_ca_system_score_gemma":0.000160195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004258558,"about_ca_topic_score_gemma":0.00001760063,"domain_scores_codex":[0.9978107,0.00007812203,0.0005843142,0.0004931406,0.0005998774,0.0004337986],"domain_scores_gemma":[0.9985967,0.0001982908,0.000193737,0.0004093454,0.0002125548,0.0003893747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001803454,0.0002734427,0.004849406,0.0007861816,0.0003031099,0.00007953178,0.01298583,0.000009098075,0.692807,0.0007688037,0.1421669,0.1431672],"study_design_scores_gemma":[0.007312917,0.0006098237,0.1560498,0.001326762,0.0003204918,0.00002276595,0.001532826,0.0007920965,0.03986979,0.0001362846,0.7914516,0.0005748375],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735408,0.005181773,0.00008428944,0.01804179,0.0006939798,0.001193044,0.00008970924,0.0003451988,0.0008294025],"genre_scores_gemma":[0.9862196,0.001319879,0.0004365451,0.001003533,0.001190274,0.0001390485,0.0006769823,0.00006068228,0.008953413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6529372,"threshold_uncertainty_score":0.8104608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013170786767824,"score_gpt":0.2771926940125205,"score_spread":0.2570609861448422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}