{"id":"W4389384453","doi":"10.1371/journal.ppat.1011822","title":"GARP and EARP are required for efficient BoHV-1 replication as identified by a genome wide CRISPR knockout screen","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; University of Toronto; University of Edinburgh; Scottish Funding Council; Wellcome Trust","keywords":"CRISPR; Biology; Endosome; Genome; Viral tegument; Viral replication; Golgi apparatus; Gene; Genome editing; Functional genomics; Capsid; Genetics; Cell biology; Computational biology; Genomics; Virus; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002127214,0.0001608981,0.000264945,0.0001487304,0.000245582,0.0000380029,0.00005212471,0.0001004496,0.0000527827],"category_scores_gemma":[0.0004664945,0.0001464631,0.0000993334,0.0003202637,0.0000453717,0.0000394973,0.00004862038,0.00007628855,0.000434749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008798729,"about_ca_system_score_gemma":0.00004236609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005076845,"about_ca_topic_score_gemma":0.0000116269,"domain_scores_codex":[0.9986745,0.00003285701,0.0002657236,0.0005183209,0.0002021888,0.0003064505],"domain_scores_gemma":[0.9988772,0.0001066088,0.0001046307,0.0005896594,0.0001370901,0.0001847795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009172915,0.003738873,0.1207133,0.0008841977,0.002052013,0.0004675625,0.002628692,0.0000844703,0.7943562,0.0004395653,0.03582179,0.03789602],"study_design_scores_gemma":[0.01222694,0.001957618,0.6094502,0.0007115752,0.002904675,0.0001791152,0.001420193,0.007967227,0.1114322,0.0009080063,0.2495596,0.001282636],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951901,0.0002771905,0.0005307634,0.0008092954,0.00007116477,0.00130636,0.0005416578,0.0002683359,0.001005097],"genre_scores_gemma":[0.9928644,0.0001280391,0.0003593862,0.0002932405,0.00009116748,0.0004442176,0.0006160584,0.00005232946,0.005151108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.682924,"threshold_uncertainty_score":0.5972593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03879928013385121,"score_gpt":0.3085003833183751,"score_spread":0.2697011031845239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}