{"id":"W4389390583","doi":"10.1038/s41586-023-06816-9","title":"Dictionary of immune responses to cytokines at single-cell resolution","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":342,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; National Human Genome Research Institute; National Cancer Institute; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Broad Institute","keywords":"Immune system; Cytokine; Biology; Cell type; T cell; Immunology; Cell; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005243799,0.0009528938,0.00126126,0.002017163,0.0006113254,0.001632721,0.0007554229,0.0005364298,0.004676939],"category_scores_gemma":[0.001565192,0.0005982977,0.001255165,0.002818569,0.0005196881,0.001034004,0.0007798798,0.00118745,0.002989228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004110443,"about_ca_system_score_gemma":0.001178032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137882,"about_ca_topic_score_gemma":0.003951699,"domain_scores_codex":[0.9995463,0.00004955876,0.00006117386,0.0001964192,0.0001124874,0.00003398042],"domain_scores_gemma":[0.9989937,0.0003841903,0.0001428818,0.0001983561,0.0002108851,0.00006993146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009170501,0.0000921801,0.01293375,0.005012219,0.0003994129,0.001159082,0.0007101527,0.01171641,0.7423465,0.01278071,0.03649464,0.1754379],"study_design_scores_gemma":[0.000190515,0.0005267205,0.05778165,0.0006452627,0.0009578032,0.00392063,0.0007691642,0.08487237,0.2002369,0.05012995,0.5996422,0.0003267592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1392225,0.009929245,0.4864683,0.0009282044,0.0009689631,0.00041364,0.3192053,0.01672383,0.02614001],"genre_scores_gemma":[0.2109186,0.006253819,0.5108743,0.0009500945,0.0002782279,0.001127285,0.2569817,0.003948999,0.008666853],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004676939,"threshold_uncertainty_score":0.01564592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315117622894315,"score_gpt":0.243851186389954,"score_spread":0.2307000101610109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}