{"id":"W4389397143","doi":"10.1101/2023.12.05.570171","title":"ERK3 Is Involved in Regulating Cardiac Fibroblast Function","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Fibroblast; Cardiac function curve; Cardiac fibrosis; Internal medicine; Endocrinology; Haploinsufficiency; Fibrosis; Myofibroblast; Cardiac myocyte; Myocyte; Medicine; Biology; Heart failure; Phenotype; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009953387,0.0006579427,0.00127302,0.0006557886,0.0001407284,0.0001632592,0.0002088771,0.0009699587,0.00003425902],"category_scores_gemma":[0.0002357652,0.0006893611,0.000635441,0.0009462659,0.00008558659,0.0001294424,0.0005722194,0.001349673,0.0001572843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005808097,"about_ca_system_score_gemma":0.0006458886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002543041,"about_ca_topic_score_gemma":0.000006000976,"domain_scores_codex":[0.9961599,0.0001312406,0.0009205033,0.001374438,0.0006752583,0.0007387156],"domain_scores_gemma":[0.9972031,0.00008661831,0.0003786476,0.001539247,0.0004670535,0.000325395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001787453,0.00009606141,0.08850837,0.001744963,0.0004175977,0.00003049691,0.00004332719,0.001105669,0.9050586,0.0001039252,0.002705217,0.000007048395],"study_design_scores_gemma":[0.001346256,0.0001222757,0.8937299,0.00681948,0.0005035418,1.648984e-8,0.00003177092,0.007240381,0.08570474,0.000007541444,0.003350089,0.001143959],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927148,0.001456583,0.0004638461,0.0005798804,0.002625388,0.001187581,0.0001812202,0.0007611585,0.00002959241],"genre_scores_gemma":[0.994556,0.0003615296,0.002808295,0.0002557655,0.001514957,0.0001604658,0.000002502643,0.0002941064,0.00004639076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8193538,"threshold_uncertainty_score":0.9995558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02500489146800225,"score_gpt":0.2377404082310733,"score_spread":0.2127355167630711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}