{"id":"W4389397304","doi":"10.1021/acsinfecdis.3c00237","title":"Cholesterol-Mediated Coenzyme A Depletion in Catabolic Mutants of Mycobacteria Leads to Toxicity","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Catabolism; Coenzyme A; Biochemistry; Enzyme; Acyl-CoA; Metabolite; Cholesterol; Biology; Metabolic pathway; Sterol O-acyltransferase; Mutant; Metabolism; Chemistry; Gene; Lipoprotein; Reductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001809523,0.0004264229,0.0005029766,0.000221658,0.0001500529,0.0003395048,0.0003041391,0.0004628089,0.0007737568],"category_scores_gemma":[0.0001715272,0.00020124,0.0002835266,0.0002718325,0.0002904074,0.0001396141,0.000236168,0.0006127041,0.0003451497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577488,"about_ca_system_score_gemma":0.0002776468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001359493,"about_ca_topic_score_gemma":0.00161611,"domain_scores_codex":[0.9996777,0.00005158546,0.00005630532,0.00005224254,0.000105294,0.00005691169],"domain_scores_gemma":[0.9998271,0.00003771247,0.00004351289,0.00002627357,0.0000218563,0.00004365646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006073567,0.00002037326,0.00008949533,0.00001187556,0.000002318432,0.0000345787,0.00000518002,0.00002919337,0.999416,0.00001951931,0.00001146856,0.0002993418],"study_design_scores_gemma":[0.00001337835,0.0002440565,0.002430363,0.000004622739,0.000006226949,0.0001685183,0.00001725953,0.0007300398,0.9958637,0.00002125018,0.0004971541,0.000003473701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995682,0.0007074539,0.00191719,0.0001106882,0.00003429073,0.00003486832,0.0006378924,0.0001330012,0.0007425781],"genre_scores_gemma":[0.9942728,0.0004965559,0.002794977,0.00007716208,0.000006634653,0.00004676463,0.0005917975,0.00004333097,0.001669924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001359493,"threshold_uncertainty_score":0.00270319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007397340129547725,"score_gpt":0.2520981044790625,"score_spread":0.2447007643495148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}