{"id":"W4389397640","doi":"10.1002/jev2.12387","title":"A clinically relevant large‐scale biomanufacturing workflow to produce natural killer cells and natural killer cell‐derived extracellular vesicles for cancer immunotherapy","year":2023,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa; Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biomanufacturing; Granzyme; Cytotoxic T cell; Cancer immunotherapy; Perforin; Immune system; NK-92; Cancer research; Immunotherapy; Biology; Immunology; Chemistry; Natural killer T cell; CD8; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006708736,0.000516411,0.0002581979,0.0002715735,0.0002638255,0.0005081563,0.0003639403,0.0004600701,0.001026216],"category_scores_gemma":[0.0003703349,0.0001656551,0.0003801715,0.0001633047,0.0002651598,0.0003859933,0.0006800126,0.0005908827,0.0007518117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004826029,"about_ca_system_score_gemma":0.0005956469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006574293,"about_ca_topic_score_gemma":0.0009306516,"domain_scores_codex":[0.9996719,0.00005406914,0.00003768549,0.00008447144,0.0001179563,0.00003387861],"domain_scores_gemma":[0.9998046,0.00004252545,0.00005249134,0.0000369216,0.00004198451,0.00002167719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002144566,0.00002616797,0.00007848119,0.00002902074,0.000002555449,0.00004163552,0.00002152047,0.0005712354,0.9961779,0.0002120409,0.00009113846,0.00272668],"study_design_scores_gemma":[0.00000804245,0.000106772,0.0004460133,0.000006893231,0.000006080599,0.0001005438,0.00002377792,0.003763865,0.9908195,0.0001663812,0.004541318,0.00001079005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6298198,0.001463814,0.3596015,0.000451967,0.0001477552,0.0009374262,0.001303334,0.001672948,0.004601505],"genre_scores_gemma":[0.6937531,0.0009752186,0.298759,0.000114959,0.00002284966,0.0005550037,0.001187455,0.0002275416,0.00440492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026216,"threshold_uncertainty_score":0.003547966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152247127230762,"score_gpt":0.2789052709749542,"score_spread":0.2673827997026466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}