{"id":"W4389397708","doi":"10.1002/cncr.35130","title":"Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls","year":2023,"lang":"en","type":"review","venue":"Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Sinai Health System; Princess Margaret Cancer Centre; BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; Chinese Academy of Medical Sciences; World Health Organization; Government of Jiangsu Province; National Natural Science Foundation of China; Vanderbilt University Medical Center; Vanderbilt University","keywords":"DNA methylation; Medicine; Lung cancer; Identification (biology); Methylation; Cancer; DNA; Genetics; Oncology; Cancer research; Internal medicine; Molecular biology; Biology; Gene; Gene expression; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002892999,0.0004292557,0.0006073872,0.0008338872,0.0004551096,0.0004858299,0.0005268011,0.0006150148,0.002390387],"category_scores_gemma":[0.005139502,0.0003488621,0.001678932,0.0008829798,0.0003118032,0.0001743306,0.0003086795,0.000390406,0.0002337664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003768284,"about_ca_system_score_gemma":0.0004019364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00305623,"about_ca_topic_score_gemma":0.003403785,"domain_scores_codex":[0.9983041,0.0004697419,0.0001717738,0.000742912,0.0002088457,0.0001025696],"domain_scores_gemma":[0.9980415,0.0009879894,0.0003750345,0.0003595497,0.0001645134,0.00007132652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001239502,0.00005523349,0.9857184,0.0001166702,0.002117274,0.0002078973,0.0001114536,0.0007356112,0.004079648,0.0001799347,0.0002732219,0.005165225],"study_design_scores_gemma":[0.0002809245,0.0004178141,0.9861501,0.00003139738,0.003827615,0.0004947094,0.00008161883,0.004169554,0.002655131,0.0005245113,0.001346509,0.0000201265],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9930118,0.001090625,0.003714072,0.00007978616,0.000022116,0.00005316323,0.001719806,0.0000263626,0.0002823517],"genre_scores_gemma":[0.9970004,0.0001234406,0.0011486,0.00002432511,0.00001065922,0.00006984986,0.001411153,0.000007147763,0.0002044508],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00305623,"threshold_uncertainty_score":0.01529986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868282249242892,"score_gpt":0.3035903416395885,"score_spread":0.2849075191471596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}