{"id":"W4389404514","doi":"10.1212/wnl.98.18_supplement.1409","title":"Autoantibodies to an RNA binding protein exacerbate clinical disability and neurodegeneration in an in vivo model of multiple sclerosis (P3-4.007)","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Neurodegeneration; Multiple sclerosis; Autoantibody; In vivo; Medicine; Neuroscience; RNA-binding protein; RNA; Internal medicine; Biology; Immunology; Antibody; Disease; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006046238,0.001194872,0.0005978559,0.0009440509,0.0005550436,0.0003995689,0.0004345299,0.001304199,0.002922134],"category_scores_gemma":[0.0002191834,0.0003488859,0.0005053947,0.0003091207,0.0006128498,0.000489821,0.0002738629,0.002333862,0.0008747482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005629706,"about_ca_system_score_gemma":0.0004746827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001657466,"about_ca_topic_score_gemma":0.003273711,"domain_scores_codex":[0.9995357,0.0001201326,0.00004257203,0.00008913926,0.00008287736,0.0001295485],"domain_scores_gemma":[0.9994154,0.00008506034,0.0001481833,0.0000425864,0.00006447272,0.0002443187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001386422,0.001005827,0.0003634891,0.00004797139,0.00002609187,0.0003254305,0.00005088303,0.00009226618,0.9957249,0.0001214756,0.0002157907,0.0006394256],"study_design_scores_gemma":[0.0004192771,0.007606997,0.008807221,0.00002910499,0.00008400839,0.001460906,0.0001508385,0.002088433,0.9774932,0.0002759528,0.001568293,0.0000157774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966865,0.00044634,0.0008062768,0.0003265859,0.00008222651,0.00003853452,0.0004439603,0.00007343793,0.001096094],"genre_scores_gemma":[0.9880103,0.0005466376,0.00207145,0.0002948647,0.00005301566,0.0001523518,0.0007882853,0.0000799758,0.008003161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002922134,"threshold_uncertainty_score":0.009775579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06791803574209362,"score_gpt":0.3241641552243541,"score_spread":0.2562461194822605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}