{"id":"W4389404873","doi":"10.1212/wnl.98.18_supplement.647","title":"A multicenter, open label, single-arm, phase 3b study (CONSONANCE) to assess efficacy of ocrelizumab in patients with primary and secondary progressive multiple sclerosis: year 1 interim analysis of cognition outcomes (P1-1.Virtual)","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"","keywords":"Ocrelizumab; Medicine; Open label; Interim analysis; Multiple sclerosis; Interim; Multicenter study; Clinical endpoint; Relapsing remitting; Internal medicine; Clinical trial; Randomized controlled trial; Rituximab; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005839072,0.001729253,0.001957166,0.0003566332,0.0007338054,0.001133676,0.001263237,0.001836883,0.004179147],"category_scores_gemma":[0.00282838,0.0006040991,0.002157079,0.000445225,0.0008489225,0.001139062,0.0005677628,0.003506202,0.00107531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008156103,"about_ca_system_score_gemma":0.002890172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001228919,"about_ca_topic_score_gemma":0.004119723,"domain_scores_codex":[0.9986792,0.0006811039,0.00007910228,0.0002626881,0.0001326491,0.0001652379],"domain_scores_gemma":[0.9978258,0.0002953396,0.0005499725,0.000315091,0.0002520588,0.0007616739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8848306,0.02354521,0.01147298,0.0007996541,0.002999113,0.0001326994,0.0002044084,0.0007424785,0.01810574,0.0004377679,0.008231246,0.04849816],"study_design_scores_gemma":[0.8291636,0.1505181,0.01561567,0.00003678232,0.0006545334,0.0001263883,0.00003121175,0.0003168179,0.0009865016,0.0001745124,0.0023428,0.00003307003],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708251,0.003398572,0.001358289,0.001027472,0.0004234214,0.009996783,0.007694322,0.000216124,0.005059808],"genre_scores_gemma":[0.9612464,0.001155747,0.008080167,0.002654318,0.0005854465,0.01072821,0.01202115,0.00008377872,0.003444805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005839072,"threshold_uncertainty_score":0.03088027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1163187476597613,"score_gpt":0.3649225980562791,"score_spread":0.2486038503965178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}