{"id":"W4389429444","doi":"10.1021/acs.jmedchem.3c01236","title":"Discovery of YSR734: A Covalent HDAC Inhibitor with Cellular Activity in Acute Myeloid Leukemia and Duchenne Muscular Dystrophy","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; Ontario Ministry of Research, Innovation and Science; Government of Ontario; Canada Research Chairs; Canada Foundation for Innovation; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Chemistry; Duchenne muscular dystrophy; Histone; Epigenetics; Histone deacetylase; Myogenesis; Drug discovery; Cancer research; Biochemistry; Cell biology; Pharmacology; In vitro; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173927,0.0003851055,0.0002207084,0.0001761489,0.0001275077,0.0001703251,0.0002936591,0.0003202079,0.0009350388],"category_scores_gemma":[0.00006699826,0.0001325663,0.0001839806,0.0001531275,0.000177643,0.0001455276,0.0001933427,0.0002967844,0.0002913309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004838823,"about_ca_system_score_gemma":0.0003070049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010343,"about_ca_topic_score_gemma":0.00229283,"domain_scores_codex":[0.9999326,0.00001061785,0.000004061999,0.00001509446,0.00001758628,0.00001999377],"domain_scores_gemma":[0.9999762,0.000001527192,0.000008522677,0.000002452818,0.000003958887,0.000007457938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002315142,0.00008856316,0.0003200403,0.0001255156,0.00002055538,0.0001996892,0.00002890392,0.0007065943,0.9715794,0.0008744847,0.0006147712,0.02520997],"study_design_scores_gemma":[0.00009555834,0.001555627,0.00148013,0.00001107399,0.00003279644,0.0006114197,0.00001372605,0.001173444,0.9812869,0.00009662004,0.01363236,0.00001025734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602385,0.01211764,0.01457615,0.0006814293,0.0001025571,0.0003022949,0.0007175131,0.0004846813,0.0107792],"genre_scores_gemma":[0.9854533,0.004291052,0.004850772,0.0001406782,0.00001491039,0.00004372771,0.0003314441,0.00001546131,0.004858709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010343,"threshold_uncertainty_score":0.003510833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006763002857175085,"score_gpt":0.2472269382167579,"score_spread":0.2404639353595828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}