{"id":"W4389430282","doi":"10.1016/j.cllc.2023.12.001","title":"Brief Report: Updated Efficacy and Safety Data From an Integrated Analysis of Entrectinib in Locally Advanced/Metastatic ROS1 Fusion-Positive Non–Small-Cell Lung Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Manchester Biomedical Research Centre; National Institutes of Health; National Cancer Institute; National Institute for Health and Care Research; F. Hoffmann-La Roche","keywords":"Medicine; ROS1; Internal medicine; Lung cancer; Oncology; Adverse effect; Population; Cancer; Clinical trial; Gastroenterology; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007788875,0.0007196801,0.001997058,0.001144679,0.0002512134,0.001911983,0.0007703798,0.0006330074,0.002681132],"category_scores_gemma":[0.008527559,0.0003563841,0.002267139,0.00188137,0.0001911218,0.001069029,0.0005676646,0.001502582,0.0008633861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001584295,"about_ca_system_score_gemma":0.001685969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001839151,"about_ca_topic_score_gemma":0.00354826,"domain_scores_codex":[0.9964039,0.0009117375,0.000432521,0.0003394033,0.001673034,0.0002394115],"domain_scores_gemma":[0.9856325,0.003499886,0.005069504,0.0009329511,0.003898361,0.0009667461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.08250722,0.002635526,0.166477,0.008568332,0.02816447,0.001113396,0.0003189839,0.007064099,0.01876037,0.000793233,0.1736103,0.5099871],"study_design_scores_gemma":[0.01235774,0.02645724,0.6807831,0.0009735862,0.03296209,0.002571586,0.0001303105,0.004069955,0.01037873,0.0006988888,0.2283867,0.0002299401],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6657637,0.06779051,0.008029845,0.009702192,0.002287393,0.00278295,0.2149124,0.001317952,0.02741303],"genre_scores_gemma":[0.7495319,0.02391276,0.005757759,0.007192558,0.003963185,0.001125252,0.2010656,0.0003401583,0.007110874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007788875,"threshold_uncertainty_score":0.04119205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03765262139459042,"score_gpt":0.4413842334711998,"score_spread":0.4037316120766093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}