{"id":"W4389434053","doi":"10.1097/hc9.0000000000000345","title":"Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance","year":2023,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"University of Colorado Denver; Children's Healthcare of Atlanta; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Children's Hospital of Pittsburgh; National Center for Advancing Translational Sciences; University of Southern California; Children's Hospital Colorado; Cincinnati Children's Hospital Medical Center; University of Washington; Saint Louis University; Emory University; Seattle Children's Research Institute; University of Pennsylvania; Hospital for Sick Children; Northwestern University; University of Cincinnati; University of Pittsburgh; Cystic Fibrosis Foundation; Children's Hospital Los Angeles; Gilead Sciences; University of California, San Francisco; Children's Hospital of Philadelphia","keywords":"Cholestasis; Medicine; Alpha 1-antitrypsin deficiency; Disease; Liver disease; Alpha (finance); Neonatal cholestasis; Pediatrics; Internal medicine; Gastroenterology; Biliary atresia; Surgery; Liver transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006943449,0.0002822326,0.0004286567,0.0007053477,0.0004447308,0.0004819544,0.0002616981,0.0002519382,0.002717608],"category_scores_gemma":[0.001962142,0.0001459897,0.0003623117,0.0007366763,0.0003243202,0.000421905,0.0003839169,0.0004386839,0.0002410532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002804951,"about_ca_system_score_gemma":0.0004467095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002041404,"about_ca_topic_score_gemma":0.002775969,"domain_scores_codex":[0.9995223,0.0001228055,0.00004854869,0.0001277332,0.00009386981,0.00008474215],"domain_scores_gemma":[0.9981768,0.0002946374,0.001112798,0.00007236841,0.0001258642,0.0002175136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003600246,0.000006251441,0.9984829,0.000006423175,0.000009003887,0.0002119569,0.00004934685,0.000006286751,0.0002778638,0.00001380163,0.00003881884,0.0008613034],"study_design_scores_gemma":[0.000002132644,0.00006070719,0.9964714,0.0000117936,0.00001692573,0.002805237,0.000198258,0.00003514038,0.0001492194,0.00002626477,0.0002209902,0.000001973212],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985781,0.0005494432,0.0001217115,0.00008951894,0.000009670905,0.00000689129,0.0001866689,0.00000493273,0.0004530685],"genre_scores_gemma":[0.9992392,0.0002812974,0.0001871716,0.00003902209,0.0000207931,0.000008917636,0.0001301829,0.000003199068,0.00009017839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002717608,"threshold_uncertainty_score":0.009091318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637585352950726,"score_gpt":0.2570110421921878,"score_spread":0.2406351886626805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}